Document Detail

The immune response to class I-associated tumor-specific cutaneous T-cell lymphoma antigens.
MedLine Citation:
PMID:  8751976     Owner:  NLM     Status:  MEDLINE    
In order to determine whether the neoplastic T cells from patients with cutaneous T-cell lymphoma express tumor-specific antigens that can serve as the targets of an immune response, we took advantage of family-specific monoclonal antibodies, magnetic bead technology, and recombinant cytokines, which provided the previously precluded ability to isolate and expand populations of purified tumor and autologous CD8 cytotoxic T cells. Four patients with advanced cutaneous T-cell lymphoma had CD8 cells that specifically killed autologous tumor in a class I limited fashion. Tumor cell cytolysis could be specifically enhanced by pre-culture with autologous gamma-irradiated tumor. The cytolytic T cells produced tumor necrosis factor-alpha in response to stimulation with autologous tumor. The presence of tumor-specific cytotoxic T cells recognizing distinctive class I associated molecules on cutaneous T-cell lymphoma tumor cells suggests that infiltration of early lesions by CD8 cells reflects host immunity to the neoplasm. These studies provide the foundation for the development of tumor vaccines through the use of cytotoxic T cells to isolate and characterize tumor-associated cutaneous T-cell lymphoma peptides.
C L Berger; N Wang; I Christensen; J Longley; P Heald; R L Edelson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  107     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-12-10     Completed Date:  1996-12-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  392-7     Citation Subset:  IM; X    
Department of Dermatology, Yale University, School of Medicine, New Haven, Connecticut 06510, USA.
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MeSH Terms
Antibody Formation
CD8-Positive T-Lymphocytes / metabolism,  pathology
Cell Division
Cells, Cultured
Clone Cells
Histocompatibility Antigens Class I / immunology*
Lymphoma, T-Cell, Cutaneous / genetics,  immunology*,  pathology
Skin Neoplasms / genetics,  immunology*,  pathology
T-Lymphocytes, Cytotoxic / immunology,  physiology
Tumor Necrosis Factor-alpha / biosynthesis
Grant Support
Reg. No./Substance:
0/Epitopes; 0/Histocompatibility Antigens Class I; 0/Tumor Necrosis Factor-alpha

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