Document Detail


The immune response of sheep to subclinical chronic exposure to the herbicide Bentazon TP.
MedLine Citation:
PMID:  1287969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A study of the effect of the Czechoslovakian herbicide BENTAZON TP on cells of the sheep immune system was carried out over a 3-mo period. A temporary decline in the number of T-lymphocytes in the peripheral blood was seen after 6 w of daily feeding of the herbicide. Dose-dependent statistically significant changes in the leucocyte migration index (p < 0.05) were seen at daily doses of 1/10 the LD50 (195 mg/kg body weight) and 1/20 the LD50 (97.5 mg/kg body weight) the 8th and 10th w of feeding, respectively. Significant changes of phagocytic activity and in the phagocytic index were not observed.
Authors:
I Mikula; J Pistl; P Kacmar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  34     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-03-16     Completed Date:  1993-03-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-9     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, University of Veterinary Medicine, Kosice, Czechoslovakia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzothiadiazines / toxicity*
Herbicides / toxicity*
Immune System / drug effects*
Lethal Dose 50
Phagocytosis / drug effects
Sheep / immunology*
T-Lymphocytes / drug effects
Chemical
Reg. No./Substance:
0/Benzothiadiazines; 0/Herbicides; 25057-89-0/bentazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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