| An immune paradox: how can the same chemokine axis regulate both immune tolerance and activation?: CCR6/CCL20: a chemokine axis balancing immunological tolerance and inflammation in autoimmune disease. | |
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MedLine Citation:
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PMID: 20954179 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Chemokines (chemotactic cytokines) drive and direct leukocyte traffic. New evidence suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key homing signals for recently identified cells of the adaptive immune system, recruiting both pro-inflammatory and suppressive T cell subsets. Thus CCR6 and CCL20 have been recently implicated in various human pathologies, particularly in autoimmune disease. These studies have revealed that targeting CCR6/CCL20 can enhance or inhibit autoimmune disease depending on the cellular basis of pathogenesis and the cell subtype most affected through different CCR6/CCL20 manipulations. Here, we discuss the significance of this chemokine receptor/ligand axis in immune and inflammatory functions, consider the potential for targeting CCR6/CCL20 in human autoimmunity and propose that the shared evolutionary origins of pro-inflammatory and regulatory T cells may contribute to the reason why both immune activation and regulation might be controlled through the same chemokine pathway. |
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Authors:
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Iain Comerford; Mark Bunting; Kevin Fenix; Sarah Haylock-Jacobs; Wendel Litchfield; Yuka Harata-Lee; Michelle Turvey; Julie Brazzatti; Carly Gregor; Phillip Nguyen; Ervin Kara; Shaun R McColl |
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Publication Detail:
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Type: Journal Article Date: 2010-10-15 |
Journal Detail:
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Title: BioEssays : news and reviews in molecular, cellular and developmental biology Volume: 32 ISSN: 1521-1878 ISO Abbreviation: Bioessays Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510851 Medline TA: Bioessays Country: United States |
Other Details:
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Languages: eng Pagination: 1067-76 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 WILEY Periodicals, Inc. |
Affiliation:
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School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia, Australia. iain.comerford@adelaide.edu.au |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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