Document Detail

The immune contexture of primary and metastatic human tumours.
MedLine Citation:
PMID:  24487185     Owner:  NLM     Status:  Publisher    
A tumour grows in a complex microenvironment composed of stromal cells, lymphoid and myeloid cells, vascular and lymphatic vessels, and the resultant cytokine and chemokine milieu. In most primary tumours, a strong Th1/cytotoxic T cells infiltration correlates with a longer survival. This beneficial effect can be hampered by the presence of M2 polarized macrophages and high VEGF production. Recent studies revealed that the pattern of the tumour microenvironment remains a major prognostic factor even in the metastatic lesions, while been reproducible between the primary and metastatic tumour. Nevertheless the prognostic impact of the Th1/cytotoxic T cell infiltrate could be different according to the origin of the primary tumour. This model highlights a novel tumour cell-dependent immune contexture that predicts patient's clinical outcome and has implications in the use of immunotherapies.
Nicolas A Giraldo; Etienne Becht; Romain Remark; Diane Damotte; Catherine Sautès-Fridman; Wolf H Fridman
Related Documents :
10408955 - Immune mechanisms in fish skin against monogeneans--a model.
1755325 - A possible pathomechanism of the idiopathic cold contact urticaria.
16954785 - Interaction of keratinocytes with infiltrating lymphocytes in allergic eczematous skin ...
20944655 - Rxrα ablation in epidermal keratinocytes enhances uvr-induced dna damage, apoptosis, an...
3144175 - Defective anti-listerial responses in deciduoma of pseudopregnant mice.
11435485 - Retardation of early-onset pma-induced apoptosis in mouse neutrophils deficient in myel...
Publication Detail:
Type:  REVIEW     Date:  2014-1-30
Journal Detail:
Title:  Current opinion in immunology     Volume:  27C     ISSN:  1879-0372     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  8-15     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  In vitro growth characteristics and volatile sulfur compound production of Solobacterium moorei.
Next Document:  The promoter of the Arabidopsis PIN6 auxin transporter enabled strong expression in the vasculature ...