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The immune contexture of primary and metastatic human tumours.
MedLine Citation:
PMID:  24487185     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A tumour grows in a complex microenvironment composed of stromal cells, lymphoid and myeloid cells, vascular and lymphatic vessels, and the resultant cytokine and chemokine milieu. In most primary tumours, a strong Th1/cytotoxic T cells infiltration correlates with a longer survival. This beneficial effect can be hampered by the presence of M2 polarized macrophages and high VEGF production. Recent studies revealed that the pattern of the tumour microenvironment remains a major prognostic factor even in the metastatic lesions, while been reproducible between the primary and metastatic tumour. Nevertheless the prognostic impact of the Th1/cytotoxic T cell infiltrate could be different according to the origin of the primary tumour. This model highlights a novel tumour cell-dependent immune contexture that predicts patient's clinical outcome and has implications in the use of immunotherapies.
Authors:
Nicolas A Giraldo; Etienne Becht; Romain Remark; Diane Damotte; Catherine Sautès-Fridman; Wolf H Fridman
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Publication Detail:
Type:  REVIEW     Date:  2014-1-30
Journal Detail:
Title:  Current opinion in immunology     Volume:  27C     ISSN:  1879-0372     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  8-15     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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