Document Detail


The immune complex pathogenesis of glomerulonephritis and pulmonary vasculitis in Behçet's disease.
MedLine Citation:
PMID:  156498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A kidney and lung biopsy were performed on a patient with active Behçet's disease with renal and pulmonary involvement. Histologic, immunohistochemical and electron microscopic studies of the kidney biopsy specimen revealed a focal segmental necrotizing glomerulonephritis characterized by the presence of numerous subendothelial and occasional intramembranous deposits containing immunoglobulin G (IgG), the third component of complement (C3), the fourth component of complement (C4) and fibrin(ogen). Histologic and immunohistochemical studies of the lung biopsy specimen showed an acute venulitis and septal capillaritis associated with the presence of identical deposits within the walls of affected vessels. Circulating immune complexes were detected in the patient's serum by Raji cell assay. The findings indicate that the glomerulonephritis and pulmonary vasculitis occasionally occurring in Behçet's disease are due to the deposition of circulating antigen-antibody complexes. In addition, they strongly suggest that the majority of the major and minor manifestations of the disease, such as uveitis, cutaneous vasculitis, synovitis and meningoencephalitis, are a result of vascular immune complex deposition.
Authors:
C N Gamble; K B Wiesner; R F Shapiro; W J Boyer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  66     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-08-29     Completed Date:  1979-08-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1031-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Behcet Syndrome / immunology*,  pathology
Capillaries / immunology,  pathology
Complement C3 / analysis
Complement C4 / analysis
Female
Fibrin / analysis
Fibrinogen / analysis
Fluorescent Antibody Technique
Glomerulonephritis / immunology*
Humans
Immune Complex Diseases / immunology*
Immunoglobulin G / analysis
Kidney Glomerulus / immunology,  pathology
Lung / pathology
Middle Aged
Pulmonary Alveoli / pathology
Pulmonary Circulation*
Vasculitis / immunology*
Chemical
Reg. No./Substance:
0/Complement C3; 0/Complement C4; 0/Immunoglobulin G; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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