| The immune complex pathogenesis of glomerulonephritis and pulmonary vasculitis in Behçet's disease. | |
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MedLine Citation:
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PMID: 156498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A kidney and lung biopsy were performed on a patient with active Behçet's disease with renal and pulmonary involvement. Histologic, immunohistochemical and electron microscopic studies of the kidney biopsy specimen revealed a focal segmental necrotizing glomerulonephritis characterized by the presence of numerous subendothelial and occasional intramembranous deposits containing immunoglobulin G (IgG), the third component of complement (C3), the fourth component of complement (C4) and fibrin(ogen). Histologic and immunohistochemical studies of the lung biopsy specimen showed an acute venulitis and septal capillaritis associated with the presence of identical deposits within the walls of affected vessels. Circulating immune complexes were detected in the patient's serum by Raji cell assay. The findings indicate that the glomerulonephritis and pulmonary vasculitis occasionally occurring in Behçet's disease are due to the deposition of circulating antigen-antibody complexes. In addition, they strongly suggest that the majority of the major and minor manifestations of the disease, such as uveitis, cutaneous vasculitis, synovitis and meningoencephalitis, are a result of vascular immune complex deposition. |
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Authors:
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C N Gamble; K B Wiesner; R F Shapiro; W J Boyer |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of medicine Volume: 66 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1979 Jun |
Date Detail:
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Created Date: 1979-08-29 Completed Date: 1979-08-29 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1031-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Behcet Syndrome
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immunology*,
pathology Capillaries / immunology, pathology Complement C3 / analysis Complement C4 / analysis Female Fibrin / analysis Fibrinogen / analysis Fluorescent Antibody Technique Glomerulonephritis / immunology* Humans Immune Complex Diseases / immunology* Immunoglobulin G / analysis Kidney Glomerulus / immunology, pathology Lung / pathology Middle Aged Pulmonary Alveoli / pathology Pulmonary Circulation* Vasculitis / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Complement C4; 0/Immunoglobulin G; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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