Document Detail


The immotile-cilia syndrome compared to other obstructive lung diseases: a clue to their pathogenesis.
MedLine Citation:
PMID:  6604645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twentyfour adults, aged 19-47 years, with congenitally nonfunctioning cilia were investigated by clinical examination, radiography, spirometry, and in most cases by tracheobronchial clearance measurements and ultrastructural examination of respiratory tract cilia and/or sperm tails. They all suffered from chronic bronchitis, rhinitis and sinusitis, and most of them had bronchiectasis and a history of otitis. Most had spirometrically overt obstructive lung disease and four radiological signs of emphysema. Clinical profile, lung function and mucociliary clearance data were compared to corresponding data from samples of patients with other obstructive lung diseases. These comparisons indicate that a long-standing impairment of mucociliary clearance is of pathogenetic importance in common chronic obstructive lung disease associated with chronic bronchitis, but not in emphysema associated with severe alpha 1-antitrypsin deficiency without chronic bronchitis, and not in asthma. In cystic fibrosis and in hypogammaglobulinemia an impaired clearance is not of primary pathogenetic significance but may contribute to the development of obstructive lung disease.
Authors:
B Mossberg; P Camner; B A Afzelius
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of respiratory diseases. Supplement     Volume:  127     ISSN:  0106-4347     ISO Abbreviation:  Eur J Respir Dis Suppl     Publication Date:  1983  
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  8010618     Medline TA:  Eur J Respir Dis Suppl     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  129-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Agammaglobulinemia / physiopathology
Asthma / physiopathology
Bronchi / physiopathology*
Bronchiectasis / physiopathology
Bronchitis / physiopathology
Cilia / physiology*,  ultrastructure
Cystic Fibrosis / physiopathology
Female
Humans
Kartagener Syndrome / physiopathology*
Lung / physiopathology
Lung Diseases, Obstructive / physiopathology*
Male
Middle Aged
Pulmonary Emphysema / physiopathology
Syndrome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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