Document Detail

The immediate pressor response to saralasin in man: a test of angiotensin II receptor vacancy.
MedLine Citation:
PMID:  214254     Owner:  NLM     Status:  MEDLINE    
Saralasin, 10 microgram/kg per min, caused an immediate rise in blood pressure in 52 of 57 (91.2%) hypertensive patients. The increase in diastolic pressure averaged 18.8 +/- 1.83 mm Hg (mean +/- SE) in normal renin patients on a normal salt intake. This immediate pressor response was absent in only five high renin patients and, conversely, was very large in three low renin patients. Direct arterial recordings are necessary to define the response accurately; it begins in 60--90 seconds, peaks in amplitude at 2.05 +/- 0.38 minutes, and subsides over the next 5 minutes in normal renin and high renin patients. The blood pressure elevation is inversely related to background plasma renin activity (r = -0.66, P less than 0.001), and also is directly, but weakly, related to 24-hour urinary sodium excretion (r = + 0.29). Therefore, the amplitude of the elevation is predictably diminished by the rise in plasma renin consequent to prior sodium restriction, and also by preliminary receptor exposure to low dose nonpressor infusions of saralasin itself (0.01-0.1 microgram/kg per min). Phentolamine had no effect on the response in two patients. We propose that the immediate pressor response to saralasin is related directly to the preexisting degree of vacancy of angiotensin II vascular receptors and that the initial agonistic action of the drug may prove useful in defining the angiotensin II receptor status in hypertensive diseases.
J M Wallace; D B Case; J H Laragh; H J Keim; J I Drayer; J E Sealey
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  44     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-02-21     Completed Date:  1979-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  IM    
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MeSH Terms
Angiotensin II* / analogs & derivatives*
Blood Pressure / drug effects*
Catecholamines / physiology
Diet, Sodium-Restricted
Hypertension / blood,  metabolism*
Infusions, Parenteral
Phentolamine / pharmacology
Receptors, Angiotensin / metabolism*
Receptors, Cell Surface / metabolism*
Renin / blood
Saralasin / administration & dosage,  diagnostic use*,  pharmacology
Sodium / metabolism
Time Factors
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Angiotensin; 0/Receptors, Cell Surface; 11128-99-7/Angiotensin II; 34273-10-4/Saralasin; 50-60-2/Phentolamine; 7440-23-5/Sodium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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