| The immediate plasma renin response to propranolol: evidence for a different mode of renin release in essential and renal hypertension. | |
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MedLine Citation:
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PMID: 1071618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The immediate short-term effects of intravenous injections of propranolol on plasma renin activity were studied in thirty-one normal subjects, 102 patients with benign essential and sixty-six patients with renal hypertension. 2. In essential hypertensive patients and normal subjects a marked fall in plasma renin activity was observed within 15 min, which was directly proportional to initial plasma renin values. In contrast, in patients with renal hypertension the fall observed was much less pronounced, or totally absent. 3. These differences in response to propranolol, which were particularly pronounced in patients with high initial renin values, suggest a dominant role of sympathetic tone at the juxtaglomerular apparatus for basal renin release in normal individuals and essential hypertensive subjects only. 4. The observations also indicate that sympathetic activity plays no part in the control of basal renin secretion in patients with renal hypertension, in whom basal renin secretion may be maintained by the renal baroreceptors. |
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Authors:
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F Skrabal; W Czaykowska; P Dittrich; H Braunsteiner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical science and molecular medicine. Supplement Volume: 3 ISSN: 0144-4107 ISO Abbreviation: Clin Sci Mol Med Suppl Publication Date: 1976 Dec |
Date Detail:
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Created Date: 1977-06-22 Completed Date: 1977-06-22 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 7907311 Medline TA: Clin Sci Mol Med Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 243s-245s Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Depression, Chemical Female Humans Hypertension / blood, physiopathology* Hypertension, Renal / blood, physiopathology* Male Middle Aged Propranolol / pharmacology* Renin / blood*, secretion Secretory Rate / drug effects |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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