| The immediate consequences of middle cerebral artery occlusion on GABA synthesis in mouse cortex and cerebellum. | |
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MedLine Citation:
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PMID: 1407654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect on gamma-aminobutyric acid (GABA) synthesis of focal ischaemia in the right cortex of the mouse was investigated by performing a right middle cerebral artery (MCA) occlusion. Synthesis of GABA was determined by measurement of the rate of GABA accumulation in tissue following injection of amino oxyacetic acid (AOAA; 30 mg/kg, i.p.). Five min following the MCA occlusion, the rate of GABA synthesis in the right (ischaemic) cortex was decreased by approximately 70% compared to either the left cortex or the right cortex of untreated controls. The basal GABA concentration was however unaffected. Four hours after the occlusion the rate of GABA synthesis was similar in the right and left cortex. The rate of GABA accumulation in the cerebellum was unchanged at both times after the right MCA occlusion compared with untreated control mice. The data suggest that there is a rapid but short lasting decrease in GABA synthesis following an ischaemic insult and it is suggested that this might be associated with the EEG spiking activity that occurs at this time. |
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Authors:
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A R Green; A J Cross; M F Snape; R J De Souza |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 138 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-10-26 Completed Date: 1992-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 141-4 Citation Subset: IM |
Affiliation:
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Astra Neuroscience Research Unit, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminooxyacetic Acid
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pharmacology* Animals Cerebellum / drug effects, metabolism* Cerebral Arteries / physiology* Cerebral Cortex / drug effects, metabolism* Functional Laterality Ischemic Attack, Transient / metabolism* Isoquinolines / metabolism Kinetics Male Mice Mice, Inbred C57BL Time Factors gamma-Aminobutyric Acid / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Isoquinolines; 56-12-2/gamma-Aminobutyric Acid; 645-88-5/Aminooxyacetic Acid; 85340-56-3/PK 11195 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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