Document Detail

The immature monkey as a model for studies of bronchopulmonary dysplasia.
MedLine Citation:
PMID:  114617     Owner:  NLM     Status:  MEDLINE    
The monkey is a potential model for BPD since there is considerable background information on the normal-developing lung, the prematurely delivered infant is viable, HMD can be produced, the infant is large enough to permit physiologic measurements, and it should be possible to test the effects of positive pressure, oxygen, and pharmacologic agents. Clearly further information is needed on the cellular and subcellular changes occurring during the acute and recovery stages of HMD. The monkey has already proven to be of value in this inquiry. Studies on mechanisms of altered lung repair by various injurious agents are needed, and will require an animal model as well as in vitro systems. Basic understanding of the pathogenesis of bronchopulmonary dysplasia with establishment of the relative importance of the contributing factors should help in our efforts to prevent or minimize chronic lung disease in the newborn infant.
W A Hodson; D L Luchtel; D L Kessler; J Murphy; S Palmer; W E Truog; T A Standaert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  95     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1979-12-29     Completed Date:  1979-12-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  895-904     Citation Subset:  AIM; IM    
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MeSH Terms
Disease Models, Animal*
Hyaline Membrane Disease / complications
Infant, Newborn
Infant, Newborn, Diseases / pathology*
Lung / pathology*
Lung Diseases / pathology*

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