Document Detail

The imbalance between coagulation and fibrinolysis is related to the severity of the illness and the prognosis in sepsis.
MedLine Citation:
PMID:  10461428     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The coagulation and fibrinolytic system appears to be activated by the septic process independently, leading to the syndrome of disseminated intravascular coagulation (DIC). In this study, we investigated the changes within the hemostatic system related to the severity of the illness and the prognosis in patients with sepsis. METHODS: Plasma thrombin-antithrombin III (TAT) and plasmin-alpha 2-antiplasmin (PAP) complexes were measured using ELISA methods in 32 patients with sepsis and 20 controls and were analyzed according to the APACHE III scores and survival of the patients. RESULTS: Plasma TAT and PAP in patients with sepsis were significantly higher than controls. Nonsurvivors showed greater levels of TAT (21.7 +/- 22.3 ng/mL) and lower levels of PAP (628.4 +/- 378.1 ng/mL) than survivors (TAT: 11.1 +/- 11.2 ng/mL; PAP: 857.1 +/- 364.1 ng/mL). The imbalance between coagulation and fibrinolysis described as TAT/PAP ratio was closely related with APACHE III scores in patients with sepsis (r = 0.47) and the TAT/PAP ratio in nonsurvivors was significantly higher compared with survivors (34.4 +/- 21.4 vs. 14.4 +/- 13.8). CONCLUSION: In sepsis, both coagulation and the fibrinolysis system are activated and the imbalance between coagulation and fibrinolysis predisposes to the hypercoagulation state and is closely related to the severity of the disease and the prognosis.
K J Park; H J Kim; S C Hwang; S M Lee; Y H Lee; M H Hahn; S K Kim; W Y Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Korean journal of internal medicine     Volume:  14     ISSN:  1226-3303     ISO Abbreviation:  Korean J. Intern. Med.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-10-12     Completed Date:  1999-10-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8712418     Medline TA:  Korean J Intern Med     Country:  KOREA (SOUTH)    
Other Details:
Languages:  eng     Pagination:  72-7     Citation Subset:  IM    
Department of Pulmonology, Ajou University School of Medicine, Suwon, Korea.
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MeSH Terms
Antithrombin III / metabolism
Blood Coagulation*
Case-Control Studies
Fibrinolysin / metabolism
Middle Aged
Sepsis / blood*
Thrombin / metabolism
alpha-2-Antiplasmin / metabolism
Reg. No./Substance:
0/alpha-2-Antiplasmin; 9000-94-6/Antithrombin III; EC; EC

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