Document Detail

The imbalance of T helper 17/regulatory T cells and memory B cells during the early post-transplantation period in peripheral blood of living donor liver transplantation recipients under calcineurin inhibitor-based immunosuppression.
MedLine Citation:
PMID:  23205589     Owner:  NLM     Status:  MEDLINE    
There is limited clinical research regarding the changes in peripheral lymphocyte subsets during the early post-operative period of liver transplantation. Serial changes of T cells and B cells in living donor liver transplantation (LDLT) recipients during the early post-transplantion period were prospectively investigated. From June 2010 to February 2011, 27 consecutive LDLT recipients were enrolled. Percentages of T helper type 1 (Th1; interferon-γ-producing), Th2 (interleukin-4-producing), Th17 (interleukin-17-producing), regulatory T (Treg; CD4(+) CD25(+) FoxP3(+) ), memory B (CD19(+) CD24(hi) CD38(-) ) and mature B (CD19(+) CD24(int) CD38(int) ) cells were measured using fluorescence-activated cell sorting. Patients were followed up for a median of 9.9 months (range 6.8-15.5 months) after transplantation. Serial monitoring of immunological profiles showed no significant suppression of Th1, Th2, Th17, mature B or memory B cells, whereas frequencies of Treg cells significantly decreased. Interleukin-17 production by central and effector memory cells was not suppressed during the early post-operative period. The continuous production of interleukin-17 by the memory T cells may contribute to the persistence of Th17 cells. This prospective study demonstrated that current immunosuppression maintained the effector T or memory B cells during the early post-transplantation period but significantly suppressed Treg cells. Serial immune monitoring may suggest clues for optimal or individualized immunosuppression during the early post-operative period in clinical practice.
Hee Yeon Kim; Mi-La Cho; Joo Yeon Jhun; Jae Kyeong Byun; Eun-Kyung Kim; Ye Been Yim; Byung Ha Chung; Seung Kew Yoon; Si Hyun Bae; Dong Goo Kim; Chul Woo Yang; Jong Young Choi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology     Volume:  138     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-03-11     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  England    
Other Details:
Languages:  eng     Pagination:  124-33     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
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MeSH Terms
B-Lymphocytes / immunology*,  pathology
Calcineurin / antagonists & inhibitors*,  immunology
Cyclosporine / administration & dosage*
Follow-Up Studies
Immunologic Memory / drug effects*
Immunosuppression / methods
Immunosuppressive Agents / administration & dosage*
Liver Transplantation*
Living Donors*
Middle Aged
Postoperative Period
Prospective Studies
Retrospective Studies
T-Lymphocytes, Regulatory / immunology*,  pathology
Tacrolimus / administration & dosage*
Th1 Cells / immunology,  pathology
Th17 Cells / immunology*,  pathology
Th2 Cells / immunology,  pathology
Reg. No./Substance:
0/Immunosuppressive Agents; 83HN0GTJ6D/Cyclosporine; EC; WM0HAQ4WNM/Tacrolimus

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