| PET/CT imaging: The incremental value of assessing the glucose metabolic phenotype and the structure of cancers in a single examination. | |
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MedLine Citation:
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PMID: 20097498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PET/CT with the glucose analogue FDG is emerging as the most important diagnostic imaging tool in oncology. More than 2000 PET/CT scanners are operational worldwide and its unique role for diagnosing, staging, restaging and therapeutic monitoring in cancer is undisputed. Studies conducted in thousands of cancer patients have clearly indicated that the combination of molecular PET with anatomical CT imaging provides incremental diagnostic value over PET or CT alone. State of the art imaging protocols combine fully diagnostic CT scans with quality whole body PET surveys. The current review briefly describes the biological alterations of cancer cells that result in their switch to a strongly glycolytic phenotype. Different whole body imaging protocols are discussed. We summarize the evidence for the incremental value of PET/CT over CT and PET alone using imaging of sarcoma as an example. Following this section we discuss the performance of FDG-PET/CT imaging for staging, restaging and monitoring of head and neck cancer, solitary lung nodules and lung cancer, breast cancer, colorectal cancer, lymphoma and unknown primary tumors. Finally, the recently emerging evidence of a substantial impact of PET/CT imaging on patient management is presented. |
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Authors:
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Johannes Czernin; Matthias R Benz; Martin S Allen-Auerbach |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-01-25 |
Journal Detail:
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Title: European journal of radiology Volume: 73 ISSN: 1872-7727 ISO Abbreviation: Eur J Radiol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 470-80 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Molecular and Medical Pharmacology, Ahmanson Biological, Imaging Center/Nuclear Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-6948, USA. jczernin@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Contrast Media Fluorodeoxyglucose F18 / diagnostic use Glucose / metabolism* Glycolysis / physiology* Humans Neoplasm Staging Neoplasms / metabolism*, pathology, radiography*, radionuclide imaging* Phenotype Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Tomography, X-Ray Computed / methods* Whole Body Imaging / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Radiopharmaceuticals; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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