| PET/CT imaging in systemic lupus erythematosus. | |
| | |
MedLine Citation:
|
PMID: 21718325 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Systemic lupus erythematosus (SLE) is the classical immune-complex disease. Involvement of vital organs, particularly the kidneys and brain, accounts for significant morbidity and mortality. A number of imaging tools are currently available for evaluation of inflammatory conditions. By targeting the increased glucose uptake of infiltrating granulocytes and tissue macrophages, positron emission tomography with fluorine-18 fluorodeoxyglucose ([(18) F]FDG PET/CT) has been shown to delineate inflammation with high sensitivity. Because activated lymphocytes have increased glucose metabolism, [(18) F]FDG PET has been successfully used to visualize large concentrations of these cells in lymphoid organs where antigen presentation and lymphocyte activation occur. Widespread increased FDG uptake in lymph nodes of patients with active SLE, as well as increased thymic uptake, has been described. The most prevalent and dramatic PET/CT finding in neuropsychiatric SLE (NP-SLE) patients is parieto-occipital hypometabolism. In conclusion, PET/CT has become an excellent ancillary tool to assess disease activity and prognosis in SLE patients. |
| | |
Authors:
|
Rodolfo Curiel; Esma A Akin; Gregory Beaulieu; Louis Depalma; Mandana Hashefi |
Related Documents
:
|
7580775 - Treitz redux: the ligament of treitz revisited. 12740465 - Dedicated multidetector ct of the stomach: spectrum of diseases. 11469575 - Clinical, clinicopathologic, radiographic, and ultrasonographic characteristics of inte... 11796905 - Volume-rendered 3d ct of the mesenteric vasculature: normal anatomy, anatomic variants,... 3561785 - Lateral pontine tegmental hemorrhage presenting as isolated trigeminal sensory neuropathy. 18044565 - Tract-based morphometry. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Annals of the New York Academy of Sciences Volume: 1228 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-07-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 71-80 Citation Subset: IM |
Copyright Information:
|
© 2011 New York Academy of Sciences. |
Affiliation:
|
Division of Rheumatology, Department of Medicine, The George Washington University Medical Center, Washington, District of Columbia. Division of Nuclear Medicine, Department of Radiology, The George Washington University Medical Center, Washington, District of Columbia. Department of Pathology, The George Washington University Medical Center, Washington, District of Columbia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: PET in vasculitis.
Next Document: PET/CT in diagnosis of dementia.