Document Detail

An imaginative approach to synovitis--the role of hypoxic reperfusion damage in arthritis.
MedLine Citation:
PMID:  8501748     Owner:  NLM     Status:  MEDLINE    
The rheumatoid joint is hypoxic. The loss of the physiologic defense mechanism, reflex muscle inhibition, allows the generation of high intraarticular pressures, particularly during exercise. Hypoxia alters the biochemistry of the synovium and encourages the production of reactive oxygen species (ROS) on reperfusion of blood. In excess, ROS damage tissues, and the products of oxidative damage are detectable in rheumatoid synovial fluid. In addition to damaging proteins, carbohydrates and lipids, cellular and structural damage also occurs.
S E Edmonds; D R Blake; C J Morris; P G Winyard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of rheumatology. Supplement     Volume:  37     ISSN:  0380-0903     ISO Abbreviation:  J Rheumatol Suppl     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-01     Completed Date:  1993-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806058     Medline TA:  J Rheumatol Suppl     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  26-31     Citation Subset:  IM    
Bone and Joint Research Unit, London Hospital Medical College, UK.
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MeSH Terms
Anoxia / pathology,  physiopathology*
Arthritis / pathology,  physiopathology*
Calcium / physiology
Reactive Oxygen Species / metabolism
Reperfusion Injury / physiopathology
Synovitis / pathology,  physiopathology*
Reg. No./Substance:
0/Reactive Oxygen Species; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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