| An illustrated review of early pancreas development in the mouse. | |
| | |
MedLine Citation:
|
PMID: 17881611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pancreas morphogenesis and cell differentiation are highly conserved among vertebrates during fetal development. The pancreas develops through simple budlike structures on the primitive gut tube to a highly branched organ containing many specialized cell types. This review presents an overview of key molecular components and important signaling sources illustrated by an extensive three-dimensional (3D) imaging of the developing mouse pancreas at single cell resolution. The 3D documentation covers the time window between embryonic days 8.5 and 14.5 in which all the pancreatic cell types become specified and therefore includes gene expression patterns of pancreatic endocrine hormones, exocrine gene products, and essential transcription factors. The 3D perspective provides valuable insight into how a complex organ like the pancreas is formed and a perception of ventral and dorsal pancreatic growth that is otherwise difficult to uncover. We further discuss how this global analysis of the developing pancreas confirms and extends previous studies, and we envisage that this type of analysis can be instrumental for evaluating mutant phenotypes in the future. |
| | |
Authors:
|
Mette Christine Jørgensen; Jonas Ahnfelt-Rønne; Jacob Hald; Ole D Madsen; Palle Serup; Jacob Hecksher-Sørensen |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2007-09-19 |
Journal Detail:
|
Title: Endocrine reviews Volume: 28 ISSN: 0163-769X ISO Abbreviation: Endocr. Rev. Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-10-09 Completed Date: 2007-11-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006258 Medline TA: Endocr Rev Country: United States |
Other Details:
|
Languages: eng Pagination: 685-705 Citation Subset: IM |
Affiliation:
|
Hagedorn Research Institute, Department of Developmental Biology, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark. mecj@hagedorn.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Differentiation Embryo, Mammalian / cytology, metabolism Embryonic Development Mice / embryology* Pancreas / embryology* Pancreas, Exocrine / embryology Peptide Hormones / metabolism Stem Cells / metabolism Transcription Factors / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
DK072473/DK/NIDDK NIH HHS; DK072495/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Peptide Hormones; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Activity-dependent NFATc3 nuclear accumulation in pericytes from cortical parenchymal microvessels.
Next Document: Splanchnic spillover of extracellular lipase-generated fatty acids in overweight and obese humans.