| The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man. | |
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MedLine Citation:
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PMID: 6706215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The possibility that malabsorbed fat passing through the human ileum exerts an inhibitory feedback control on jejunal motility has been investigated in 24 normal subjects by perfusing the ileum with a fat containing solution designed to produce ileal luminal fat concentrations similar to those in steatorrhoea (30-40 mg/ml). Mean transit times through a 30 cm saline perfused jejunal segment were measured by a dye dilution technique. Thirty minutes after ileal fat perfusion, mean transit times rose markedly to 18.9 +/- 2.5 minutes from a control value of 7.5 +/- 0.9 minutes (n = 5; p less than 0.05). This was associated with an increase in volume of the perfused segment which rose to 175.1 +/- 22.9 ml (control 97.6 +/- 10.3 ml, n = 5; p less than 0.05). Transit times and segmental volumes had returned towards basal values 90 minutes after completing the fat perfusion. Further studies showed that ileal fat perfusion produced a pronounced inhibition of jejunal pressure wave activity, percentage duration of activity falling from a control level of 40.3 +/- 5.0% to 14.9 +/- 2.8% in the hour after ileal perfusion (p less than 0.01). Ileal fat perfusion was associated with marked rises in plasma enteroglucagon and neurotensin, the peak values (218 +/- 37 and 68 +/- 13.1 pmol/l) being comparable with those observed postprandially in coeliac disease. These observations show the existence in man of an inhibitory intestinal control mechanism, whereby ileal fat perfusion inhibits jejunal motility and delays caudal transit of jejunal contents. |
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Authors:
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R C Spiller; I F Trotman; B E Higgins; M A Ghatei; G K Grimble; Y C Lee; S R Bloom; J J Misiewicz; D B Silk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gut Volume: 25 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-05-04 Completed Date: 1984-05-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 365-74 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Celiac Disease / physiopathology Female Gastrointestinal Motility* Glucagon-Like Peptides / blood Humans Ileum / physiology* Jejunum / physiology* Male Manometry Neurotensin / blood Perfusion Triglycerides / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Triglycerides; 39379-15-2/Neurotensin; 62340-29-8/Glucagon-Like Peptides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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