| The identification and management of heparin-induced thrombocytopenia in the vascular patient. | |
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MedLine Citation:
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PMID: 22188737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heparin-induced thrombocytopenia (HIT) is a serious, acquired, prothrombotic disorder caused by an antibody response to the heparin-platelet factor 4 complex, which can precipitate arterial as well as venous thromboembolic complications. HIT should be suspected in patients exposed to heparin who present with an unexplained thrombosis or a significant drop in platelet count, or both. Once HIT is suspected or identified, there are specific approaches to its diagnosis and management, with emphasis on removal of all heparin compounds and administration of alternative nonheparin anticoagulants. Generally, HIT is a self-limiting syndrome that resolves when the antibody titers disappear. Patients should be anticoagulated for up to 6 months, depending on the clinical scenario; however, the management of patients with remote or recent HIT requiring a vascular procedure requires special considerations. |
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Authors:
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Glenn M LaMuraglia; Rabih Houbballah; Michael Laposata |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-12-20 |
Journal Detail:
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Title: Journal of vascular surgery Volume: 55 ISSN: 1097-6809 ISO Abbreviation: J. Vasc. Surg. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-23 Completed Date: 2012-03-12 Revised Date: 2012-10-03 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 562-70 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Vascular and Endovascular Surgery of the General Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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blood Anticoagulants / adverse effects*, immunology Drug Substitution Heparin / adverse effects*, immunology Humans Platelet Factor 4 / immunology Predictive Value of Tests Risk Assessment Risk Factors Thrombocytopenia / chemically induced, diagnosis*, immunology, therapy* Thrombosis / chemically induced, diagnosis*, immunology, therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Anticoagulants; 37270-94-3/Platelet Factor 4; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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