Document Detail

The identification and management of heparin-induced thrombocytopenia in the vascular patient.
MedLine Citation:
PMID:  22188737     Owner:  NLM     Status:  MEDLINE    
Heparin-induced thrombocytopenia (HIT) is a serious, acquired, prothrombotic disorder caused by an antibody response to the heparin-platelet factor 4 complex, which can precipitate arterial as well as venous thromboembolic complications. HIT should be suspected in patients exposed to heparin who present with an unexplained thrombosis or a significant drop in platelet count, or both. Once HIT is suspected or identified, there are specific approaches to its diagnosis and management, with emphasis on removal of all heparin compounds and administration of alternative nonheparin anticoagulants. Generally, HIT is a self-limiting syndrome that resolves when the antibody titers disappear. Patients should be anticoagulated for up to 6 months, depending on the clinical scenario; however, the management of patients with remote or recent HIT requiring a vascular procedure requires special considerations.
Glenn M LaMuraglia; Rabih Houbballah; Michael Laposata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-12-20
Journal Detail:
Title:  Journal of vascular surgery     Volume:  55     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-03-12     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  562-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
Division of Vascular and Endovascular Surgery of the General Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
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MeSH Terms
Antibodies / blood
Anticoagulants / adverse effects*,  immunology
Drug Substitution
Heparin / adverse effects*,  immunology
Platelet Factor 4 / immunology
Predictive Value of Tests
Risk Assessment
Risk Factors
Thrombocytopenia / chemically induced,  diagnosis*,  immunology,  therapy*
Thrombosis / chemically induced,  diagnosis*,  immunology,  therapy*
Treatment Outcome
Reg. No./Substance:
0/Antibodies; 0/Anticoagulants; 37270-94-3/Platelet Factor 4; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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