Document Detail


The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster.
MedLine Citation:
PMID:  9545646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Drosophila Polycomb group (PcG) of genes is required for the epigenetic regulation of a number of important developmental genes, including the homeotic (Hox) genes. The members of this gene family encode proteins that do not share sequence similarity, implying that each plays a unique role in this epigenetic repression mechanism. Polycomblike (Pcl) was the second PcG gene to be identified. We report here the isolation and characterization of a human cDNA, termed PHF1, which encodes a protein with significant sequence similarity to Drosophila Polycomblike (PCL). The region of similarity between PHF1 and PCL includes the two PHD fingers (C4-H-C3 motif), the region between them, and sequences C-terminal to the PHD fingers. PHF1 and PCL are 34% identical over this 258-residue region. PHF1 was mapped to 6p21.3 by fluorescence in situ hybridization. While several genetic diseases that are likely to result from developmental abnormalities map to this region, PHF1 is not a clear candidate gene for any of them.
Authors:
M Coulson; S Robert; H J Eyre; R Saint
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  48     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-06-08     Completed Date:  1998-06-08     Revised Date:  2012-03-13    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-3     Citation Subset:  IM    
Affiliation:
Department of Genetics, University of Adelaide, Australia.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF029678
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Chromosomes, Human, Pair 6
DNA, Complementary
DNA-Binding Proteins*
Drosophila Proteins*
Drosophila melanogaster / genetics*
Humans
Mice
Molecular Sequence Data
Proteins / chemistry,  genetics*
Repressor Proteins / chemistry,  genetics*
Sequence Alignment
Sequence Homology, Amino Acid
Transcription Factors*
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/PHF1 protein, human; 0/Pcl protein, Drosophila; 0/Proteins; 0/Repressor Proteins; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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