Document Detail

The identification for high risk group of gastric cancer using serum pepsinogen after successful eradication of Helicobacter pylori.
MedLine Citation:
PMID:  23034090     Owner:  NLM     Status:  Publisher    
BACKGROUND: Pepsinogen (PG) method is widely used to identify high risk group of gastric cancer.It is very useful before Helicobacter pylori (H. pylori) eradication, but after eradication the method becomes useless because PGI, PGII, PGI/II ratio change. Therefore, we aimed to identify for high risk group of gastric cancer using serum pepsinogen after successful eradication of H. pylori. METHODS: 261 Participants after successful eradication H. pylori in Hokkaido University Hospital from 1995 to 2010 were enrolled. Participants with renal failure, taking Proton Pomp Inhibitor, advanced gastric cancer were excluded. Serum levels of PGI and II were measured using Chemiluminescent Immuno Assey (CLIA) method. RESULTS: ROC curve using cancerous and non-cancerous data in post-eradication determined the optimal cut-off value of PGI/II was 4.5. The sensitivity and the specificity were 65.9% and 79.3%. Usual PG method includes 48.9% of cancer cases, and the PGI/II≦4.5 in post-eradication includes 65.9% of them, and it includes approximately half of the high risk group of diffuse type cancer. PGI/II≦4.5 in post-eradication included many gastric cancer cases detected after eradication (12/16=75%). CONCLUSION: As the identification for high risk group of gastric cancer, we suggest that the opotimal cut-off value of PGI/II after successful eradication of H. pylori is 4.5. PGI/II≦4.5 in post-eradication includes more gastric cancer cases comparing with traditional PG method, and 75% of gastric cancer cases detected after eradication.
M Haneda; M Kato; S Ishigaki; M Suzuki; M Takahashi; M Nakagawa; S Ono; Y Mori; K Mabe; S Nakagawa; T Kudo; Y Shimizu; M Asaka
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo,, Japan.
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