Document Detail

The identification of genetic pathways involved in vascular adaptations after physical deconditioning versus exercise training in humans.
MedLine Citation:
PMID:  23064509     Owner:  NLM     Status:  Publisher    
Physical inactivity and exercise training result in opposite adaptations of vascular structure. However, the molecular mechanisms behind these adaptations are not completely understood. Therefore, we used a unique study design to examine both vascular characteristics of the superficial femoral artery (using ultrasound) and gene expression levels (from a muscle biopsy) in human models for physical deconditioning and exercise training. First, we compared able-bodied controls (n=6) with spinal cord-injured (SCI) individuals (n=8) to assess the effects of long-term deconditioning. Subsequently, able-bodied controls underwent short-term lower limb deconditioning using 3 weeks of unilateral limb suspension. SCI individuals were examined before and after 6 weeks functional electrical stimulation exercise training. Baseline diameter and hyperemic flow were lower after short- and long-term deconditioning and higher after exercise training, whilst intima-media thickness/lumen ratio was increased with short- and long-term deconditioning and decreased with exercise training. Regarding gene expression levels of vasculature-related genes, we found that groups of genes including the vascular endothelial growth factor (VEGF) pathway, transforming growth factor beta 1 (TGFB1), and extracellular matrix (ECM) proteins strongly related with vascular adaptations in humans. This approach resulted in the identification of important genes that may be involved in vascular adaptations after physical deconditioning and exercise.
Gerwen Lammers; Noortje T L van Duijnhoven; Joost G Hoenderop; Astrid M Horstman; Arnold de Haan; Thomas W J Janssen; Mark J J de Graaf; Elisabeth M Pardoel; Eugène T P Verwiel; Dick H J Thijssen; Maria T E Hopman
Related Documents :
10368359 - Age and renal prostaglandin inhibition during exercise and heat stress.
9592469 - Current status of research on pelvic muscle strengthening techniques.
20086499 - Treatment of exercise incontinence with a urethral insert: a pilot study in women.
12044019 - Intravaginal surface emg probe design test for urinary incontinence patients.
476919 - Determination of 4-o-methylated catecholamine metabolites in urine by mass fragmentogra...
23878369 - Temporal response of positive and negative regulators in response to acute and chronic ...
22867749 - The anabolic potential of dietary protein intake on skeletal muscle is prolonged by pri...
9325469 - Effect of voice rehabilitation on oral communication of parkinson's disease patients.
16516909 - Within-species variability of the response to 20-hydroxyecdysone in peach-potato aphid ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Radboud University Nijmegen Medical Centre;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Understanding the physiology of heart failure through cellular and in vivo models towards targeting ...
Next Document:  Imaging the healing myocardial infarct-ultrasound, MRI and near-infrared fluorescence.