Document Detail


The identification of QTL that affect the fatty acid composition of milk on sheep chromosome 11.
MedLine Citation:
PMID:  19968648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this work, we analysed 11 genetic markers localized on OAR11 in a commercial population of Spanish Churra sheep to detect QTL that underlie milk fatty acid (FA) composition traits. Following a daughter design, we analysed 799 ewes distributed in 15 half-sib families. Eight microsatellite markers and three novel SNPs identified in two genes related to fatty acid metabolism, acetyl-CoA carboxylase alpha (ACACA) and fatty acid synthase (FASN), were genotyped in the whole population under study. The phenotypic traits considered in the study included 22 measurements related to the FA composition of the milk and three other milk production traits (milk protein percentage, milk fat percentage and milk yield). Across-family regression analysis revealed four significant QTL at the 5% chromosome-wise level influencing contents of capric acid (C10:0), lauric acid (C12:0), linoleic conjugated acid (CLA) and polyunsaturated fatty acids (PUFA) respectively. The peaks of the QTL affecting C10:0 and PUFA contents in milk map close to the FASN gene, which has been evaluated as a putative positional candidate for these QTL. The QTL influencing C12:0 content reaches its maximum significance at 58 cM, close to the gene coding for the glucose-dependent insulinotropic polypeptide. We were not able to find any candidate genes related to fat metabolism at the QTL influencing CLA content, which is located at the proximal end of the chromosome. Further research efforts will be needed to confirm and refine the QTL locations reported here.
Authors:
M García-Fernández; B Gutiérrez-Gil; E García-Gámez; J P Sánchez; J J Arranz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-26
Journal Detail:
Title:  Animal genetics     Volume:  41     ISSN:  1365-2052     ISO Abbreviation:  Anim. Genet.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-08-17     Revised Date:  2012-04-17    
Medline Journal Info:
Nlm Unique ID:  8605704     Medline TA:  Anim Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  324-8     Citation Subset:  IM    
Affiliation:
Departamento de Producción Animal, Facultad de Veterinaria, Universidad de León, 24071, León, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosomes, Mammalian
Fatty Acids / analysis*,  biosynthesis
Milk / chemistry*
Quantitative Trait Loci*
Sheep / genetics*,  metabolism
Chemical
Reg. No./Substance:
0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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