Document Detail


iPS cell technology in regenerative medicine.
MedLine Citation:
PMID:  20392216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The promise of treating human genetic and degenerative diseases through the application of pluripotent cell-based tissue engineering and regenerative medicine has come significantly closer to realization since the isolation of human embryonic stem (ES) cells. While the study of ES cells has greatly increased our fundamental understanding of pluripotency, technical and ethical limitations have been seemingly insurmountable impediments to the application of these cells in the clinic. The recent discovery that somatic mammalian cells can be epigenetically reprogrammed to a pluripotent state through the exogenous expression of the transcription factors OCT4, SOX2, KLF4, and c-MYC has yielded a new cell type for potential application in regenerative medicine, the induced pluripotent stem (iPS) cell. Here we discuss how advances in iPS cell technology have led to the generation of patient-specific cell lines that can potentially be used to model human diseases and ultimately act as therapeutic agents.
Authors:
Christopher J Lengner
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Publication Detail:
Type:  Historical Article; Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1192     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-15     Completed Date:  2010-05-05     Revised Date:  2010-10-19    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  IM    
Affiliation:
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA. lengner@wi.mit.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Culture Techniques / history,  methods
History, 21st Century
Humans
Induced Pluripotent Stem Cells / physiology*,  transplantation,  virology
Models, Biological
Mutagenesis, Insertional / methods
Regenerative Medicine / history,  methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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