Document Detail


The iC3b receptor of Candida albicans and its roles in pathogenesis.
MedLine Citation:
PMID:  19388174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
On the basis of biochemical and immunologic studies, a receptor for iC3b with some activities reminiscent of the integrins CD11b and CD11c was defined on the cell wall of clinical and laboratory isolates of Candida albicans. The INT1 gene encodes a protein of 1659 amino acids; the Int1 protein participates in adhesion to epithelial cells in vitro and in vivo. Int1 is essential for hyphal morphogenesis and virulence in a murine model. Recent evidence points to the amino terminus of Int1 as the source of a peptide, Pep263, with superantigen-like activities.
Authors:
Margaret K Hostetter
Related Documents :
7876304 - Human sec13rp functions in yeast and is located on transport vesicles budding from the ...
15498024 - Manganese toxicity and saccharomyces cerevisiae mam3p, a member of the acdp (ancient co...
1368914 - Expression of high levels of human tissue plasminogen activator in yeast under the cont...
8879274 - Self-association of human rad52 protein.
8865344 - In vivo association of protein fragments giving active arac.
3181134 - Cdna cloning of the developmentally regulated lamin liii of xenopus laevis.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Vaccine     Volume:  26 Suppl 8     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-04-23     Completed Date:  2009-05-05     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  I108-12     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adhesiveness
Candida albicans / pathogenicity*
Cell Adhesion Molecules / chemistry,  genetics,  physiology*
Cloning, Molecular
Fungal Proteins / chemistry,  genetics,  physiology*
Heparin / pharmacology
Receptors, Complement 3b / physiology*
Virulence
Grant Support
ID/Acronym/Agency:
R01 AI050813/AI/NIAID NIH HHS; R01 AI050813-01A1/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Fungal Proteins; 0/Receptors, Complement 3b; 0/alphaINT1 protein, Candida albicans; 9005-49-6/Heparin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Complement and its role in protection and pathogenesis of flavivirus infections.
Next Document:  Microbial complement inhibitors as vaccines.