| The iC3b receptor of Candida albicans and its roles in pathogenesis. | |
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MedLine Citation:
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PMID: 19388174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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On the basis of biochemical and immunologic studies, a receptor for iC3b with some activities reminiscent of the integrins CD11b and CD11c was defined on the cell wall of clinical and laboratory isolates of Candida albicans. The INT1 gene encodes a protein of 1659 amino acids; the Int1 protein participates in adhesion to epithelial cells in vitro and in vivo. Int1 is essential for hyphal morphogenesis and virulence in a murine model. Recent evidence points to the amino terminus of Int1 as the source of a peptide, Pep263, with superantigen-like activities. |
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Authors:
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Margaret K Hostetter |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Vaccine Volume: 26 Suppl 8 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-04-23 Completed Date: 2009-05-05 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: Netherlands |
Other Details:
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Languages: eng Pagination: I108-12 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Yale School of Medicine, 333 Cedar Street, LMP 4085, P.O. Box 208064, New Haven, CT 06520-8064, USA. margaret.hostetter@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adhesiveness Candida albicans / pathogenicity* Cell Adhesion Molecules / chemistry, genetics, physiology* Cloning, Molecular Fungal Proteins / chemistry, genetics, physiology* Heparin / pharmacology Receptors, Complement 3b / physiology* Virulence |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI050813-01A1/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Fungal Proteins; 0/Receptors, Complement 3b; 0/alphaINT1 protein, Candida albicans; 9005-49-6/Heparin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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