| The hypoxic ventilatory response of rats with increased blood oxygen affinity. | |
| | |
MedLine Citation:
|
PMID: 3809758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Experimental work has established an interspecific relationship between the threshold for the hypoxic ventilatory response and the 'knee' of the Hb-O2 dissociation curve. However, whether this relationship exists intraspecifically remains unclear. To examine the problem further rats were treated with sodium cyanate (NaOCN) to lower P50 and their hypoxic ventilatory response was measured. NaOCN treated rats had a lower PaO2 and higher Hct than control rats. There was no difference between the control and lowered P50 condition in the ventilatory response to hypoxia when % delta VI was plotted against PaO2. The results are consistent with PaO2 sensing chemoreceptors. |
| | |
Authors:
|
G F Birchard; S M Tenney |
Related Documents
:
|
7942058 - Erythropoietin response to acute hypobaric or anaemic hypoxia in gentamicin-administere... 15661838 - Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilat... 8647728 - Combined effects of adrenalectomy and noise exposure on compound action potentials, end... 21410058 - Protective effects of ursodeoxycholic acid against immune-mediated liver fibrosis in rats. 13945358 - Studies on the stability of vitamin a in the stomach and small intestine. 20005408 - Expression of mesenchymal, hematopoietic, and biliary cell markers in adult rat hepatoc... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Respiration physiology Volume: 66 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1986 Nov |
Date Detail:
|
Created Date: 1987-03-06 Completed Date: 1987-03-06 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 225-33 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cyanates / pharmacology Hematocrit Male Oxygen / blood* Rats Rats, Inbred Strains Respiration* / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
HL 02888-28/HL/NHLBI NIH HHS; HL 07449-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cyanates; 7782-44-7/Oxygen; 917-61-3/sodium cyanate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of hypothalamic lesions on the cardiorespiratory responses to muscular contraction.
Next Document: Effect of graded anesthesia on laryngeal-induced central apnea.