Document Detail

The hypoxic placenta.
MedLine Citation:
PMID:  22994517     Owner:  NLM     Status:  In-Data-Review    
Abstract Martha C. Tissot van Patot, Martha C., German Ebensperger, Max Gassmann, and Aníbal J. Llanos. The hypoxic placenta. High Alt Med Biol. 13:176-184, 2012. -Hypoxia of the placenta is integral to complications of pregnancy, including preeclampsia, intrauterine growth restriction, and small-for-gestational age babies. Hypoxia in the placenta is associated with vascular remodeling, hypertension, metabolic changes, oxidative stress, mitochondrial dysfunction, and endoplasmic reticular stress. Hypoxia induces similar outcomes in other organs such as the lungs, kidney, and gut. Comparing and contrasting the effects of hypoxia on placental functions and functions of lung, kidney, and gut can lead to novel hypotheses and investigations, furthering our understanding of the impact of hypoxia on these diverse yet similar organs. In this review, we compare and contrast hypoxic placental responses to those in the other organ and cell systems.
Martha C Tissot van Patot; German Ebensperger; Max Gassmann; Aníbal J Llanos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  13     ISSN:  1557-8682     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  176-84     Citation Subset:  IM; S    
1 Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology (ZIHP), University of Zürich , Zürich, Switzerland .
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