Document Detail

A hypothetical relationship between the nuclear reprogramming factors for induced pluripotent stem (iPS) cells generation - bioinformatic and algorithmic approach.
MedLine Citation:
PMID:  21195557     Owner:  NLM     Status:  Publisher    
A hypothetical evolutionary relationship was generated between the nuclear reprogramming factors for induced pluripotent stem (iPS) cells generation. Utilizing bioinformatics techniques, sequence analyses and phylogenetic tree algorithms, a comparative study has been performed to understand the evolutionary relationship of human nuclear reprogramming factors of induced pluripotent stem cells (iPSCs) generation. Among the total six nuclear reprogramming factors, the four reprogramming factors (SOX2, C-MYC, KLF4, and LIN28) have significant evolutionary origin. Our study shows SOX2 and C-MYC have evolutionary relationship and common point of origin. Likewise, KLF4 and LIN28 are having evolutionary relationship and have common point of origin. Based on these evidences, we propose that our study may be a great help to the future researchers to understand the mechanism(s) as well as pathway of nuclear reprogramming process.
Sanjiban Sekhar Roy; C H Hsu; Z H Wen; C S Lin; Chiranjib Chakraborty
Related Documents :
2564417 - Human cytomegalovirus induces stage-specific embryonic antigen 1 in differentiating hum...
15333777 - Derivation, growth and applications of human embryonic stem cells.
18638137 - Male germ cell transplantation.
19571877 - Elite and stochastic models for induced pluripotent stem cell generation.
11698267 - Direct evidence that leukemic cells present hla-associated immunogenic peptides derived...
6406547 - Immunoglobulin a nephropathy. quantitative immunohistomorphometry of the tonsillar plas...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-30
Journal Detail:
Title:  Medical hypotheses     Volume:  -     ISSN:  1532-2777     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
School of Computing Science and Engineering, VIT University, Vellore, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characterizing binge drinking among U.S. military Veterans receiving a brief alcohol intervention.
Next Document:  Relationship between the prenatal exposure to low-level of mercury and the size of a newborn's cereb...