Document Detail

A hypothesis concerning the general basis of organogenetic congenital anomalies.
MedLine Citation:
PMID:  3605239     Owner:  NLM     Status:  MEDLINE    
Evidence supports the idea that it is the degree of metabolic imbalance present in diabetic gravid women during the period of organogenesis that accounts for organogenetic congenital defects. In light of the proved and inferred metabolic instability occurring during early pregnancy, we propose that metabolic imbalances may occur that result in organogenetic congenital defects in offspring of apparently normal gravid women.
F Naftolin; M P Diamond; E Pinter; E A Reece; M K Sanyal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  157     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-08-25     Completed Date:  1987-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  AIM; IM    
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MeSH Terms
Abnormalities, Multiple / embryology,  etiology*
Diabetes Mellitus / metabolism
Embryonic and Fetal Development
Pregnancy in Diabetics / metabolism*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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