Document Detail


The hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 in chicks.
MedLine Citation:
PMID:  14720603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was carried out to investigate whether the hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 (GLP-1) in chicks. To examine this, Fos expression in the chick hypothalamus were immunohistochemically detected after intracerebroventricular (ICV) injection of 30-pmol GLP-1. ICV injection of GLP-1 stimulated the expression of Fos-like immunoreactive (FLI) cells in the ventromedial hypothalamic nucleus (VMN). When 15-pmol GLP-1 was directly injected into the chick VMN, the chick's food intake was significantly decreased compared with the control treatment. Microinjection of GLP-1 into the (LHA) also inhibited feeding in chicks, although ICV injection of GLP-1 did not stimulate FLI expression in the brain area. These results suggest that VMN and some brain regions are involved in the anorexic effect of GLP-1 in chicks.
Authors:
Tetsuya Tachibana; Keiko Hirofuji; Mako Matsumoto; Mitsuhiro Furuse; Shin Hasegawa; Fumiaki Yoshizawa; Kunio Sugahara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  137     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-14     Completed Date:  2004-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
Affiliation:
United Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan. tetsu@brs.kyushu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Anorexia / physiopathology*
Chickens
Feeding Behavior / physiology
Glucagon / administration & dosage,  physiology*
Glucagon-Like Peptide 1
Hypothalamus / cytology,  physiology*
Injections, Intraventricular
Male
Peptide Fragments / administration & dosage,  physiology*
Protein Precursors / administration & dosage,  physiology*
Proto-Oncogene Proteins c-fos / analysis
Ventromedial Hypothalamic Nucleus / metabolism
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/Protein Precursors; 0/Proto-Oncogene Proteins c-fos; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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