| The hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 in chicks. | |
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MedLine Citation:
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PMID: 14720603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was carried out to investigate whether the hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 (GLP-1) in chicks. To examine this, Fos expression in the chick hypothalamus were immunohistochemically detected after intracerebroventricular (ICV) injection of 30-pmol GLP-1. ICV injection of GLP-1 stimulated the expression of Fos-like immunoreactive (FLI) cells in the ventromedial hypothalamic nucleus (VMN). When 15-pmol GLP-1 was directly injected into the chick VMN, the chick's food intake was significantly decreased compared with the control treatment. Microinjection of GLP-1 into the (LHA) also inhibited feeding in chicks, although ICV injection of GLP-1 did not stimulate FLI expression in the brain area. These results suggest that VMN and some brain regions are involved in the anorexic effect of GLP-1 in chicks. |
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Authors:
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Tetsuya Tachibana; Keiko Hirofuji; Mako Matsumoto; Mitsuhiro Furuse; Shin Hasegawa; Fumiaki Yoshizawa; Kunio Sugahara |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Volume: 137 ISSN: 1095-6433 ISO Abbreviation: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-14 Completed Date: 2004-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9806096 Medline TA: Comp Biochem Physiol A Mol Integr Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 183-8 Citation Subset: IM |
Affiliation:
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United Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan. tetsu@brs.kyushu-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anorexia / physiopathology* Chickens Feeding Behavior / physiology Glucagon / administration & dosage, physiology* Glucagon-Like Peptide 1 Hypothalamus / cytology, physiology* Injections, Intraventricular Male Peptide Fragments / administration & dosage, physiology* Protein Precursors / administration & dosage, physiology* Proto-Oncogene Proteins c-fos / analysis Ventromedial Hypothalamic Nucleus / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/Protein Precursors; 0/Proto-Oncogene Proteins c-fos; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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