Document Detail

The hypothalamic-pituitary-adrenal axis in asthmatic children.
MedLine Citation:
PMID:  18155557     Owner:  NLM     Status:  MEDLINE    
Reduced responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis in patients with various chronic allergic inflammatory disorders and a blunted HPA axis response of poorly controlled asthmatics before long-term treatment with inhaled corticosteroids (ICS) have been reported. It seems that pro- and anti-inflammatory cytokines might be involved in the attenuation of cortisol and adrenocorticotropic hormone (ACTH) responses to stress in these patients. Although long-term ICS treatment might produce mild adrenal suppression in some asthmatic children, improvement of adrenal function has been detected in the majority of cases. We postulate that the anti-inflammatory effects of ICS result both in asthma remission and HPA axis improvement. Adrenal suppression of some asthmatic patients on maintenance ICS seems to be a separate phenomenon, possibly constitutionally or genetically determined.
Kostas N Priftis; Anastasios Papadimitriou; Polyxeni Nicolaidou; George P Chrousos
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-12-26
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  19     ISSN:  1043-2760     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-07     Completed Date:  2008-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-8     Citation Subset:  IM    
Department of Allergy-Pneumonology, Penteli Children's Hospital, Athens, Greece.
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MeSH Terms
Administration, Inhalation
Adrenal Cortex Hormones / administration & dosage,  therapeutic use
Anti-Asthmatic Agents / administration & dosage,  therapeutic use
Asthma / drug therapy,  pathology,  physiopathology*
Hypothalamo-Hypophyseal System / drug effects,  metabolism,  physiopathology*
Models, Biological
Pituitary-Adrenal System / drug effects,  metabolism,  physiopathology*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Asthmatic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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