| The hypoblast (visceral endoderm): an evo-devo perspective. | |
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MedLine Citation:
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PMID: 22354839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When amniotes appeared during evolution, embryos freed themselves from intracellular nutrition; development slowed, the mid-blastula transition was lost and maternal components became less important for polarity. Extra-embryonic tissues emerged to provide nutrition and other innovations. One such tissue, the hypoblast (visceral endoderm in mouse), acquired a role in fixing the body plan: it controls epiblast cell movements leading to primitive streak formation, generating bilateral symmetry. It also transiently induces expression of pre-neural markers in the epiblast, which also contributes to delay streak formation. After gastrulation, the hypoblast might protect prospective forebrain cells from caudalizing signals. These functions separate mesendodermal and neuroectodermal domains by protecting cells against being caught up in the movements of gastrulation. |
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Authors:
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Claudio D Stern; Karen M Downs |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 139 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-22 Completed Date: 2012-04-16 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 1059-69 Citation Subset: IM |
Affiliation:
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Department of Cell and Developmental Biology, University College London, GowerStreet (Anatomy Building), London WC1E 6BT, UK. c.stern@ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amnion
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metabolism,
physiology Animals Biological Evolution* Body Patterning / genetics* Chick Embryo Embryonic Induction / genetics Endoderm / embryology Gastrulation* Gene Expression Regulation, Developmental Germ Layers / physiology* Mice Nervous System / embryology Nutritional Physiological Phenomena Primitive Streak / physiology |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council; //Medical Research Council |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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