Document Detail


The hypoblast (visceral endoderm): an evo-devo perspective.
MedLine Citation:
PMID:  22354839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When amniotes appeared during evolution, embryos freed themselves from intracellular nutrition; development slowed, the mid-blastula transition was lost and maternal components became less important for polarity. Extra-embryonic tissues emerged to provide nutrition and other innovations. One such tissue, the hypoblast (visceral endoderm in mouse), acquired a role in fixing the body plan: it controls epiblast cell movements leading to primitive streak formation, generating bilateral symmetry. It also transiently induces expression of pre-neural markers in the epiblast, which also contributes to delay streak formation. After gastrulation, the hypoblast might protect prospective forebrain cells from caudalizing signals. These functions separate mesendodermal and neuroectodermal domains by protecting cells against being caught up in the movements of gastrulation.
Authors:
Claudio D Stern; Karen M Downs
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  139     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-22     Completed Date:  2012-04-16     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  1059-69     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amnion / metabolism,  physiology
Animals
Biological Evolution*
Body Patterning / genetics*
Chick Embryo
Embryonic Induction / genetics
Endoderm / embryology
Gastrulation*
Gene Expression Regulation, Developmental
Germ Layers / physiology*
Mice
Nervous System / embryology
Nutritional Physiological Phenomena
Primitive Streak / physiology
Grant Support
ID/Acronym/Agency:
G0400559//Medical Research Council; //Biotechnology and Biological Sciences Research Council; //Medical Research Council
Comments/Corrections

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