Document Detail

The hypertrophic heart rat: a new normotensive model of genetic cardiac and cardiomyocyte hypertrophy.
MedLine Citation:
PMID:  11948289     Owner:  NLM     Status:  MEDLINE    
We describe a new line of rats with inherited cardiomyocyte and ventricular hypertrophy. From a second-generation cross of spontaneously hypertensive and Fischer 344 rats, we selected for low blood pressure and either high or low echocardiographic left ventricular (LV) mass over four generations to establish the hypertrophic heart rat (HHR) and normal heart rat (NHR) lines, respectively. After 13 generations of inbreeding, HHR had significantly greater (P < 0.0001) LV mass-to-body weight ratio (2.68 g/kg, SE 0.14) than NHR matched for age (1.94 g/kg, SE 0.02) or body weight (2.13 g/kg, SE 0.03). The isolated cardiomyocytes of HHR were significantly (P < 0.0001) longer and wider (161 microm, SE 0.83; 35.6 microm, SE 2.9) than NHR (132 microm, SE 1.2; 29.5 microm, SE 0.35). Telemetric 24-h recordings of mean arterial pressure revealed no significant differences between HHR and NHR. The HHR offers a new model of primary cardiomyocyte hypertrophy with normal blood pressure in which to examine genotypic causes and pathogenetic mechanisms of hypertrophy and its complications.
Stephen B Harrap; Vennetia R Danes; Justine A Ellis; Cory D Griffiths; Elizabeth F Jones; Leanne M D Delbridge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiological genomics     Volume:  9     ISSN:  1531-2267     ISO Abbreviation:  Physiol. Genomics     Publication Date:  2002  
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9815683     Medline TA:  Physiol Genomics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-8     Citation Subset:  IM    
Department of Physiology, University of Melbourne, Australia.
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MeSH Terms
Body Weight / physiology
Breeding / methods
Crosses, Genetic
Disease Models, Animal*
Heart / physiology
Hypertension / genetics*,  physiopathology
Hypertrophy, Left Ventricular / genetics*,  physiopathology*
Myocardium / pathology*
Organ Size / physiology
Rats, Inbred F344
Rats, Inbred SHR

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