Document Detail


The "hypertriglyceridemic waist" phenotype and glucose intolerance in pregnancy.
MedLine Citation:
PMID:  20855478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Abdominal visceral adiposity in early pregnancy has been associated with impaired glucose tolerance in later pregnancy. The "hypertriglyceridemic waist" phenotype (i.e., abdominal obesity in combination with hyper-triglyceridemia) is a clinical marker of visceral obesity. Our study aimed to assess the association between the hyper-triglyceridemic-waist phenotype in early pregnancy and glucose intolerance in later pregnancy.
METHODS: Plasma triglycerides and waist girth were measured at 11-14 weeks of gestation among 144 white pregnant women. Glycemia was measured following a 75-g oral glucose tolerance test performed at 24-28 weeks of gestation.
RESULTS: A waist girth greater than 85 cm in combination with a triglyceride level ≥ 1.7 mmol/L in the first trimester was associated with an increased risk of two-hour glucose ≥ 7.8 mmol/L following the 75-g oral glucose tolerance test (odds ratio [OR] 6.1, p = 0.002). This risk remained significant even after we controlled for maternal age, fasting glucose at first trimester and previous history of gestational diabetes (OR 4.7, p = 0.02).
INTERPRETATION: Measurement of waist girth in combination with measurement of triglyceride concentrations in the first trimester of pregnancy could improve early screening for gestational glucose intolerance.
Authors:
Diane Brisson; Patrice Perron; Simon-Pierre Guay; Daniel Gaudet; Luigi Bouchard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-20
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  182     ISSN:  1488-2329     ISO Abbreviation:  CMAJ     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2010-11-02     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  E722-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Université de Montréal, Montreal, Canada. diane.brisson@ecogene21.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Diabetes, Gestational / metabolism,  physiopathology
Female
Glucose Intolerance / complications*,  metabolism,  physiopathology
Glucose Tolerance Test
Humans
Hypertriglyceridemia / complications
Maternal Age
Obesity / complications
Phenotype
Pregnancy
Pregnancy Complications / metabolism*,  physiopathology
Pregnancy Trimester, First / metabolism,  physiology
Risk Factors
Waist Circumference*
Young Adult
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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