| The "hypertriglyceridemic waist" phenotype and glucose intolerance in pregnancy. | |
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MedLine Citation:
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PMID: 20855478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Abdominal visceral adiposity in early pregnancy has been associated with impaired glucose tolerance in later pregnancy. The "hypertriglyceridemic waist" phenotype (i.e., abdominal obesity in combination with hyper-triglyceridemia) is a clinical marker of visceral obesity. Our study aimed to assess the association between the hyper-triglyceridemic-waist phenotype in early pregnancy and glucose intolerance in later pregnancy. METHODS: Plasma triglycerides and waist girth were measured at 11-14 weeks of gestation among 144 white pregnant women. Glycemia was measured following a 75-g oral glucose tolerance test performed at 24-28 weeks of gestation. RESULTS: A waist girth greater than 85 cm in combination with a triglyceride level ≥ 1.7 mmol/L in the first trimester was associated with an increased risk of two-hour glucose ≥ 7.8 mmol/L following the 75-g oral glucose tolerance test (odds ratio [OR] 6.1, p = 0.002). This risk remained significant even after we controlled for maternal age, fasting glucose at first trimester and previous history of gestational diabetes (OR 4.7, p = 0.02). INTERPRETATION: Measurement of waist girth in combination with measurement of triglyceride concentrations in the first trimester of pregnancy could improve early screening for gestational glucose intolerance. |
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Authors:
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Diane Brisson; Patrice Perron; Simon-Pierre Guay; Daniel Gaudet; Luigi Bouchard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-20 |
Journal Detail:
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Title: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Volume: 182 ISSN: 1488-2329 ISO Abbreviation: CMAJ Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9711805 Medline TA: CMAJ Country: Canada |
Other Details:
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Languages: eng Pagination: E722-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Université de Montréal, Montreal, Canada. diane.brisson@ecogene21.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Diabetes, Gestational / metabolism, physiopathology Female Glucose Intolerance / complications*, metabolism, physiopathology Glucose Tolerance Test Humans Hypertriglyceridemia / complications Maternal Age Obesity / complications Phenotype Pregnancy Pregnancy Complications / metabolism*, physiopathology Pregnancy Trimester, First / metabolism, physiology Risk Factors Waist Circumference* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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