Document Detail


The hypertensive Y chromosome elevates blood pressure in F11 normotensive rats.
MedLine Citation:
PMID:  8505094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our laboratory has shown that the Y chromosome has a significant effect on blood pressure in the spontaneously hypertensive rat (SHR) model of hypertension and that the testes and androgen receptor contribute to the blood pressure rise. As an extension of our research, we have developed two new rat strains, SHR/a and SHR/y (F11) to study the Y chromosome. The objectives of the following research were 1) to study the blood pressure of rats with an SHR Y chromosome in a normotensive genetic background (SHR/y) or a normotensive Y chromosome in an SHR genetic background (SHR/a), 2) to determine the effect of male sex phenotype on the blood pressure of these rats, 3) to determine if testosterone replacement in castrated rats would restore blood pressure, and 4) to determine whether the Y chromosome from the SHR/y strain when crossed with a normotensive female can induce hypertension in androgen receptor-deficient male offspring. Blood pressure of male SHR/y rats was significantly higher than that of normotensive Wistar-Kyoto males (p < 0.01), and SHR/a males had significantly lower blood pressure compared with that of the parent SHR strain (p = 0.05). Testosterone replacement in castrated rats of both strains (SHR/a and SHR/y) restored blood pressure to control levels. Normotensive female King-Holtzman rats heterozygous for the testicular feminization gene were crossed with F11 SHR/a and SHR/y males.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
D L Ely; H Daneshvar; M E Turner; M L Johnson; R L Salisbury
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  21     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-07-02     Completed Date:  1993-07-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1071-5     Citation Subset:  IM    
Affiliation:
Department of Biology, University of Akron, OH 44325-3908.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Blood Pressure*
Female
Hybridization, Genetic
Hypertension / genetics*
Male
Orchiectomy
Rats
Rats, Inbred SHR / genetics
Rats, Inbred WKY / genetics
Receptors, Androgen / metabolism,  physiology
Reference Values
Testosterone / pharmacology
X Chromosome
Y Chromosome*
Chemical
Reg. No./Substance:
0/Receptors, Androgen; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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