Document Detail


Is hypertension predictive of clinical recurrence in posterior reversible encephalopathy syndrome?
MedLine Citation:
PMID:  23219827     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Posterior reversible encephalopathy syndrome (PRES) has a distinctive clinical presentation and typical neuroimaging findings. However, data on its clinical course and recurrence are scarce. This study aims to investigate its clinical profile and factors that predict recurrence. We included patients diagnosed with PRES between 2005 and 2010 and collected data on demographics, presenting symptoms, co-morbidities, risk factors, clinical parameters, MRI findings, complications and recurrence. Patients were categorized into two groups: PRES due to primary hypertension and PRES due to secondary causes. Correlation with presenting symptoms, radiological features, and recurrence were analyzed. PRES was identified in 28 patients. Fourteen (50%) had primary hypertension. Secondary causes included immunosuppression-related (39%), preeclampsia/eclampsia (7%), and marijuana-intake-related (4%) causes. Patients presented with altered mental status (79%), headache (75%), seizure (68%), visual disturbance (39%) and hemiparesis (21%). On MRI 93% had the typical parietal-occipital involvement. The frontal lobe was affected in 64%, cerebellum in 29%, brainstem in 21%, and basal ganglia in 11%. About 36% had cortical involvement; 21% had diffusion-restricted lesions. Non-aneurysmal subarachnoid haemorrhage was found in 18% of patients and intracerebral hemorrhage in 14% of patients. No significant difference existed in presenting symptoms and the MRI distribution of vasogenic edema between the primary hypertension group and the secondary causes group. Recurrence occurred in four patients (14.3%, 95% confidence interval 4.2-33.7) and was significantly associated (p=0.05) with primary hypertension as the etiology. Intensive monitoring and treatment of hypertension is recommended for reducing morbidity.
Authors:
Richard Li; Peter Mitchell; Richard Dowling; Bernard Yan
Related Documents :
23025387 - Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients...
23999527 - Neuropsychiatric disease relevance of circulating anti-nmda receptor autoantibodies dep...
23072397 - Cervical tumoral calcinosis with secondary hyperparathyroidism in a chronic hemodialysi...
23825757 - The use of jackson-pratt silicone flat drains as prolonged pleural catheters for the ma...
21852177 - Secondary dystonia in a botulinum toxin clinic: clinical characteristics, neuroanatomic...
23025387 - Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-6
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  -     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Neurology, Royal Melbourne Hospital, Victoria, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Novel therapeutic use of polysaccharide nanosheets for arachnoid plasty and enhancement of venous te...
Next Document:  Effects of persistent Mal de debarquement syndrome on balance, psychological traits, and motor corte...