Document Detail


Is hypertension a major risk factor in aneurysmal subarachnoid hemorrhage?
MedLine Citation:
PMID:  12212365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The role of hypertension as a major risk factor for the development and rupture of cerebral aneurysms is a subject of considerable debate. METHODS: In order to substantiate or weaken the hypothesis of the atherogenic, degenerative origin of this disease, in addition to hypertension the influence of smoking and the covariates body weight, hematocrit, fibrinogen and leukocrit were examined in a hospital-based case-control and cohort study. 141 consecutive patients with subarachnoid hemorrhage (SAH) and verified cerebral aneurysms, admitted between September 1994 and August 1998, were investigated. RESULTS: An association was found between hypertension and SAH of cerebral aneurysm in the entire patient group (P < 0.0001). In the stepwise logistic regression, the exposure odds ratio (OR) for hypertension was 6.8 (CI (95%): 3.53-13.14). Smokers have a twofold higher risk, with an OR of 2.2 (CI (95%): 1.19-4.06). Age was found to have a prognostic impact on the disease (P = 0.0089). Age obviously was a confounding factor for hypertension, which was associated with the outcome (P = 0.048). CONCLUSION: Patients with hypertension had a nearly seven-fold higher risk of aneurysmal subarchnoid hemorrhage. This seems to substantiate the hypothesis that aneurysm is an acquired and hemodynamically induced chronic disease.
Authors:
Güther Kleinpeter; Stephan Lehr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  114     ISSN:  0043-5325     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-09-05     Completed Date:  2002-10-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  307-14     Citation Subset:  IM    
Affiliation:
Neurochirurgische Abteilung, Donauspital, Wien, Austria. g.kleinpeter@billrothhaus.at
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MeSH Terms
Descriptor/Qualifier:
Aged
Aneurysm, Ruptured / etiology*
Austria
Body Weight
Case-Control Studies
Cohort Studies
Female
Fibrinogen / metabolism
Hematocrit
Humans
Hypertension / complications*
Intracranial Aneurysm / complications*
Leukocyte Count
Male
Middle Aged
Risk Factors
Smoking / adverse effects
Subarachnoid Hemorrhage / etiology*
Chemical
Reg. No./Substance:
9001-32-5/Fibrinogen
Comments/Corrections
Comment In:
Wien Klin Wochenschr. 2002 May 15;114(8-9):285-6   [PMID:  12212360 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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