Document Detail

Is hyperlipasemia in critically ill patients of clinical importance? An observational CT study.
MedLine Citation:
PMID:  17497124     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess morphological alterations of the pancreas by contrast-enhanced computed tomography (cCT) and subclinical cellular damage of the pancreas by measuring pancreatitis-associated protein (PAP) in critically ill patients without prior pancreatic disorder who presented with raised serum lipase levels. DESIGN: Prospective, observational study SETTING: Mixed surgical/neurosurgical intensive care unit of a German university hospital. PATIENTS: One hundred and thirty consecutive critically ill patients without prior damage or disease of the pancreas and an expected length of stay of more than 5 days. INTERVENTIONS: Daily serum lipase measurements and daily serum PAP measurements. Contrast-enhanced upper abdominal cCT study in patients with triple increase of serum lipase. MEASUREMENTS AND RESULTS: Thirty-eight patients showed raised serum lipase levels and qualified for the cCT scan study. In 20 patients cCT scans were performed. Morphological alterations of the pancreas were found in 7 out these 20 patients while serum PAP levels were raised in all patients. CONCLUSION: Hyperlipasemia is a common finding in critically ill patients without prior pancreatic disorder. While elevated serum PAP levels indicate pancreatic cellular stress morphological alterations of the pancreas are rare and of little clinical importance.
Christof Denz; Leonie Siegel; Karl-J?rgen Lehmann; Jean-Charles Dagorn; Fritz Fiedler
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Publication Detail:
Type:  Journal Article     Date:  2007-05-12
Journal Detail:
Title:  Intensive care medicine     Volume:  33     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-23     Completed Date:  2008-02-26     Revised Date:  2010-02-08    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1633-6     Citation Subset:  IM    
University of Heidelberg, Clinic of Anesthesiology and Intensive Care Medicine, University Hospital Mannheim, Faculty of Clinical Medicine Mannheim, 68167 Mannheim, Germany.
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MeSH Terms
Antigens, Neoplasm / blood*
Contrast Media
Critical Illness
Intensive Care Units
Iopamidol / analogs & derivatives
Lectins, C-Type / blood*
Lipase / blood*
Middle Aged
Pancreas / radiography
Pancreatitis / blood,  radiography*
Prospective Studies
Tomography, X-Ray Computed*
Tumor Markers, Biological / blood*
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Contrast Media; 0/Lectins, C-Type; 0/Tumor Markers, Biological; 0/pancreatitis-associated protein; 62883-00-5/Iopamidol; 78649-41-9/iomeprol; EC

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