| Is hyperlipasemia in critically ill patients of clinical importance? An observational CT study. | |
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MedLine Citation:
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PMID: 17497124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess morphological alterations of the pancreas by contrast-enhanced computed tomography (cCT) and subclinical cellular damage of the pancreas by measuring pancreatitis-associated protein (PAP) in critically ill patients without prior pancreatic disorder who presented with raised serum lipase levels. DESIGN: Prospective, observational study SETTING: Mixed surgical/neurosurgical intensive care unit of a German university hospital. PATIENTS: One hundred and thirty consecutive critically ill patients without prior damage or disease of the pancreas and an expected length of stay of more than 5 days. INTERVENTIONS: Daily serum lipase measurements and daily serum PAP measurements. Contrast-enhanced upper abdominal cCT study in patients with triple increase of serum lipase. MEASUREMENTS AND RESULTS: Thirty-eight patients showed raised serum lipase levels and qualified for the cCT scan study. In 20 patients cCT scans were performed. Morphological alterations of the pancreas were found in 7 out these 20 patients while serum PAP levels were raised in all patients. CONCLUSION: Hyperlipasemia is a common finding in critically ill patients without prior pancreatic disorder. While elevated serum PAP levels indicate pancreatic cellular stress morphological alterations of the pancreas are rare and of little clinical importance. |
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Authors:
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Christof Denz; Leonie Siegel; Karl-J?rgen Lehmann; Jean-Charles Dagorn; Fritz Fiedler |
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Publication Detail:
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Type: Journal Article Date: 2007-05-12 |
Journal Detail:
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Title: Intensive care medicine Volume: 33 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-23 Completed Date: 2008-02-26 Revised Date: 2010-02-08 |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1633-6 Citation Subset: IM |
Affiliation:
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University of Heidelberg, Clinic of Anesthesiology and Intensive Care Medicine, University Hospital Mannheim, Faculty of Clinical Medicine Mannheim, 68167 Mannheim, Germany. christof.denz@anaes.ma.uni-heidelberg.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, Neoplasm / blood* Contrast Media Critical Illness Female Humans Intensive Care Units Iopamidol / analogs & derivatives Lectins, C-Type / blood* Lipase / blood* Male Middle Aged Pancreas / radiography Pancreatitis / blood, radiography* Prospective Studies Tomography, X-Ray Computed* Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Contrast Media; 0/Lectins, C-Type; 0/Tumor Markers, Biological; 0/pancreatitis-associated protein; 62883-00-5/Iopamidol; 78649-41-9/iomeprol; EC 3.1.1.3/Lipase |
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