Document Detail

The hypercube structure of the genetic code explains conservative and non-conservative aminoacid substitutions in vivo and in vitro.
MedLine Citation:
PMID:  8866048     Owner:  NLM     Status:  MEDLINE    
A representation of the genetic code as a six-dimensional Boolean hypercube is described. This structure is the result of the hierarchical order of the interaction energies of the bases in codon-anticodon recognition. In this paper it is applied to study molecular evolution in vivo and in vitro. In the first case we compared aligned positions in homologous protein sequences and found two different behaviors: (a) There are sites in which the different amino acids may be explained by one or two 'attractor nodes' (coding for the dominating amino acid(s)) and their one-bit neighbors in the codon hypercube; and (b) There are sites in which the amino acids correspond to codons located in closed paths in the hypercube. In the second case we studied the 'Sexual PCR'1 experiment described by Stemmer [Stemmer (1994)] and found that the success of this combination of usual PCR and recombination is in part due to the Gray code structure of the genetic code.
M A Jiménez-Montaño; C R de la Mora-Basánez; T Pöschel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bio Systems     Volume:  39     ISSN:  0303-2647     ISO Abbreviation:  BioSystems     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-08     Completed Date:  1997-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0430773     Medline TA:  Biosystems     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  117-25     Citation Subset:  IM    
Depariamento de Fisica y Matemáticas, Universidad de las Américas, Puebla, Cholula, México.
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MeSH Terms
Amino Acids / genetics*
Genetic Code*
Polymerase Chain Reaction
Recombination, Genetic
Reg. No./Substance:
0/Amino Acids; 0/Anticodon; 0/Codon

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