| A hypercaloric load induces thermogenesis but inhibits stress responses in the SNS and HPA system. | |
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MedLine Citation:
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PMID: 9087645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caloric overingestion generates a sympathetic nervous system (SNS)-mediated increase in brown adipose tissue (BAT) thermogenesis; its effect on the hypothalamo-pituitary-adrenal (HPA) axis is unknown. To determine whether metabolic activation affects the HPA axis, male rats were provided palatable sucrose ad libitum. After 5 or 10 days of sucrose ingestion, BAT and basal and restraint-induced HPA variables were measured. Some rats were instrumented with temperature probes. BAT temperature and HPA axis responses to restraint were measured. Although caloric intake increased > or = 18%, body weight gain did not change after sucrose ingestion; DNA, protein, and uncoupling protein increased in BAT depots, and white adipose tissues were heavier after both 5 and 10 days. During days 5-10, the BAT-core temperature difference was +0.30 degrees C in sucrose rats and -0.46 degrees C in controls (P < 0.05); this, together with the biochemical changes, shows persistent activation of BAT by excess calories. Basal HPA measures were not altered. The sucrose group exhibited smaller BAT temperature and HPA responses to restraint on day 10; there was no HPA difference on day 5. We conclude that calorically mediated increases in BAT thermogenesis are independent of basal HPA activity; however, both systems respond concordantly to restraint stress. The diminished response to restraint in both systems in sucrose-fed rats may result from signals indicating increased energy stores. |
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Authors:
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A M Strack; S F Akana; C J Horsley; M F Dallman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 272 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-04-28 Completed Date: 1997-04-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R840-8 Citation Subset: IM; S |
Affiliation:
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Department of Physiology, University of California, San Francisco 94143-0444, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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physiology* Adipose Tissue, Brown / anatomy & histology, innervation, physiology* Adrenocorticotropic Hormone / blood, metabolism Analysis of Variance Animals Body Temperature Regulation* Corticosterone / blood Dietary Sucrose Energy Intake* Hypothalamo-Hypophyseal System / physiology* Male Organ Size Pituitary Gland, Anterior / physiology Pituitary-Adrenal System / physiology* Rats Rats, Sprague-Dawley Restraint, Physical Stress, Psychological* Sympathetic Nervous System / physiology*, physiopathology Weight Gain* |
| Grant Support | |
ID/Acronym/Agency:
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DK-28172/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Sucrose; 50-22-6/Corticosterone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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