| Is hypercalcemic diet a possible antidote to oral contraceptive-induced hypertension? | |
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MedLine Citation:
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PMID: 22314948 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Administration of oral contraceptive (OC) has been associated with body fluid retention and in high doses over a long period, promotes hypertension. This present investigation tests the hypothesis that the dietary calcium supplementation increases salt and water excretion in OC (norgestre/ethinylestradiol) treated 32 female albino rats randomly distributed into four (1-4) groups of 8 rats each: Control, OC-treated, OC-treated+ Calcium diet fed and Calcium diet fed only respectively. OC was administered to the appropriate groups by gavage. Experimental diet contained 2.5% calcium supplement. Plasma and urinary [Na+] [K+] were evaluated after 8 weeks of experimentation by flame photometry and plasma [Ca2+] by colorimetric method. OC-treatment induced a significant fall in urinary [Na+]. Water excretion was significantly reduced in these animals (control, 3.1±0.56 Vs OC-treated rats, 1.47±0.16). OC-treated rats had significantly higher plasma [K+] compared to control rats. Calcium supplementation induced increases in plasma [Na+], [K+] and augmented urinary Na+ excretion (OC-treated + Ca2+ diet Vs OC-treated only). Compared with the control rats, high Ca2+ diet fed rats exhibited significant increases in plasma [Na+] and [K+] accompanied by significant decreases in urinary H20 excretion. These results strongly suggest that high dietary Ca2+ supplementation increases salt and water excretion in OC-treated rats and potentially moderates fluid retention and blood pressure in these animals, and may be of clinical significance in OC-induced abnormal fluid retention and perhaps OC-induced hypertension.Keywords: Hypercalcemic-diet, Oral contraceptive, Plasma electrolytes, Hypertension, Female-albino-rats. |
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Authors:
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J I Okwusidi; K I Alabi; L A Olatunji; T O Oyesola |
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Publication Detail:
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Type: Journal Article Date: 2010-11-28 |
Journal Detail:
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Title: Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria Volume: 25 ISSN: 0794-859X ISO Abbreviation: Niger J Physiol Sci Publication Date: 2010 |
Date Detail:
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Created Date: 2012-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811109 Medline TA: Niger J Physiol Sci Country: Nigeria |
Other Details:
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Languages: eng Pagination: 115-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, College of Medicine, University of Ilorin, Ilorin. jiokwusidi@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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