| The hydroxyanilide fenhexamid, a new sterol biosynthesis inhibitor fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea). | |
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MedLine Citation:
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PMID: 11721524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fenhexamid, a recently developed botryticide, is shown here to inhibit sterol biosynthesis. When the fungus Botryotinia fuckeliana was grown in the presence of fenhexamid, the ergosterol content was reduced, and three 3-keto compounds, 4 alpha-methylfecosterone, fecosterone and episterone, accumulated, suggesting an inhibition of the 3-keto reductase involved in C-4 demethylation. Thus, fenhexamid belongs to a new, promising class of sterol biosynthesis inhibitors not previously used in agriculture or in medicine. |
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Authors:
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D Debieu; J Bach; M Hugon; C Malosse; P Leroux |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pest management science Volume: 57 ISSN: 1526-498X ISO Abbreviation: Pest Manag. Sci. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-27 Completed Date: 2002-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100898744 Medline TA: Pest Manag Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1060-7 Citation Subset: IM |
Affiliation:
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INRA, Unité de Phytopharmacie et Médiateurs Chimiques, 78026 Versailles, France. debieu@versailles.inra.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amides
/
chemistry,
metabolism,
pharmacology* Antifungal Agents / chemistry, metabolism, pharmacology Botrytis / drug effects*, growth & development, metabolism Cell Wall / drug effects Fungicides, Industrial / chemistry, metabolism, pharmacology* Molecular Structure Phytosterols / antagonists & inhibitors, biosynthesis* Plant Diseases / microbiology* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Antifungal Agents; 0/Fungicides, Industrial; 0/Phytosterols; 0/fenhexamid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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