| A hydrophobic gel phantom for study of thermochemical ablation: initial results using a weak acid and weak base. | |
| | |
MedLine Citation:
|
PMID: 19699659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To develop a model for study of exothermic chemical reactions potentially useful for tissue ablation. MATERIALS AND METHODS: Seven gelatins ranging from 0.5% to 30% wt/vol with and without 15% or 30% caps and several commercial gels were evaluated. Baseline temperature measurements were taken. Acetic acid and ammonium hydroxide were sequentially injected over periods of 10-15 seconds in 1-mL aliquots, forming a discrete aqueous reaction chamber. Congo red pH indicator was included to assess the reaction. A thermocouple allowed data collection at completion of injection and every 15 seconds for 5 minutes. Injections were performed in triplicate, and average temperatures for each time point were reported. RESULTS: Gelatins fractured or refluxed even at the lowest concentrations tested. Most commercial gels proved too viscous and likewise led to reflux along the needle tract. A mineral oil-based gel was selected because of its ability to form a chamber without reflux or fracture and its clear colorless character, hydrophobic nature, chemical stability, viscosity, specific gravity, and cost. Temperatures during the first 60 seconds of the neutralization reaction showed an immediate increase that correlated well with concentration. CONCLUSIONS: The oil gel phantom is a safe, useful, readily available, inexpensive model to study mixing behaviors and maximum heating potentials for reactions that may prove useful in thermochemical tissue ablation for oncologic interventions. Measurable temperature changes occurred even at the lowest concentrations, and higher concentrations produced a greater release of heat energy. |
| | |
Authors:
|
Andrew J Misselt; Theresa L Edelman; Jeung H Choi; John C Bischof; Erik N K Cressman |
Related Documents
:
|
21531429 - Efficiently accounting for ion correlations in electrokinetic nanofluidic devices using... 18506809 - Gel formation and low-temperature intramolecular conformation transition of a triple-he... 20685439 - Highly sensitive and selective spectrofluorimetric determination of metoclopramide hydr... 20945479 - Diffusion properties of bacteriophages through agarose gel membrane. 7358459 - Reversible gelation of arachin. 22988609 - Performance evaluation of a pilot-scale anaerobic membrane bioreactor (anmbr) treating ... 10602579 - Human adaptation to work in two different climates. 17204409 - Drug permeability across a phospholipid vesicle based barrier: 3. characterization of d... 19860549 - Insect rate-temperature relationships: environmental variation and the metabolic theory... |
Publication Detail:
|
Type: Comparative Study; Evaluation Studies; Journal Article Date: 2009-08-21 |
Journal Detail:
|
Title: Journal of vascular and interventional radiology : JVIR Volume: 20 ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-10-05 Completed Date: 2010-01-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1352-8 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN 55455, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Ablation Techniques
/
methods* Gels / chemistry*, therapeutic use Hydrogen-Ion Concentration Hydrophobicity Hyperthermia, Induced / methods* Materials Testing |
| Chemical | |
Reg. No./Substance:
|
0/Gels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Application of the segment weight dynamic movement method to the normalization of gait EMG amplitude...
Next Document: Initial in vivo studies with a polymer-based MR-compatible guide wire.