Document Detail


The hunger hormone ghrelin in cachexia.
MedLine Citation:
PMID:  23289712     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cachexia is characterized by reduced food intake, muscle and adipose tissue loss associated with increased energy expenditure. Cachexia is highly prevalent and represents one of the main causes of increased morbidity, mortality and reduced quality of life in chronic diseases. Ghrelin plays an important role in stimulating and controlling hunger and maintaining energy homeostasis acting on central nervous system and on peripheral tissues. Most of the studies have been conducted in experimental settings and in cancer and uremic patients, showing interesting results in the treatment of cachexia. Further investigations are mandatory to obtain more definitive and conclusive results.
Authors:
Alessio Molfino; Gianfranco Gioia; Maurizio Muscaritoli
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  -     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Sapienza University of Rome, Department of Clinical Medicine , Viale dell'Università 37, 00185 Rome , Italy +390649972020 ; +390649972016 ; maurizio.muscaritoli@uniroma1.it.
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