Document Detail


The human salivary protein complex (SPC): a large block of related genes.
MedLine Citation:
PMID:  9556667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have shown that genes for at least six human parotid proteins, parotid acidic protein (Pa), proline-rich protein (Pr), double-banded protein (Db), glycoprotein (Gl), parotid middle-band protein (Pm), and parotid-size variant (Ps) are linked. We have designated this complex of genes as the salivary protein complex (SPC). Several of the genes in this complex show marked associations that are most likely the result of linkage disequilibrium. It seems likely that the SPC arose through the process of gene duplication. This hypothesis is supported by the results of our present study that demonstrate the biochemical similarity of the protein products of several SPC genes. The amino acid compositions of the major SPC proteins are compared, including several (Ps 1 and 2, and Db) that have not been published. All of these proteins are quite similar and consist to a large extent of the amino acids, proline, glycine, and gix (glutamine and/or glutamic acid).
Authors:
P A Goodman; P L Yu; E A Azen; R C Karn
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of human genetics     Volume:  37     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1998-04-28     Completed Date:  1998-04-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  785-97     Citation Subset:  IM    
Affiliation:
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis 46223, USA.
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MeSH Terms
Descriptor/Qualifier:
Computers
Female
Humans
Linkage (Genetics)
Lod Score
Male
Multigene Family
Salivary Proteins and Peptides / genetics*
Grant Support
ID/Acronym/Agency:
1R01-DE05684/DE/NIDCR NIH HHS; 5-T32-DE07043/DE/NIDCR NIH HHS; DE0-3658-19/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Salivary Proteins and Peptides
Comments/Corrections

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