| The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome. | |
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MedLine Citation:
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PMID: 20435609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is widely recognized that bi-directional communication exists between the human oocyte and cumulus cells (CCs) which is essential for the production of competent oocytes. CCs originate from granulosa cells (GCs) which differentiate into mural GCs and CCs during follicular antrum formation. CCs are biologically distinct from other follicular cells and perform specialized roles, transmitting signals within the ovary and supporting oocyte growth and maturation during the later stages of follicular development. This review details the results of transcriptomic analysis of CCs and considers what this data can teach us about the biology of CCs and their interactions with the oocyte. We also explore the potential for the gene expression data to reveal novel biomarkers of oocyte quality and assist the optimization of assisted reproductive technologies. |
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Authors:
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Zhongwei Huang; Dagan Wells |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-04-29 |
Journal Detail:
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Title: Molecular human reproduction Volume: 16 ISSN: 1460-2407 ISO Abbreviation: Mol. Hum. Reprod. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2010-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513710 Medline TA: Mol Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 715-25 Citation Subset: IM |
Affiliation:
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Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Oxford, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cumulus Cells
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metabolism*,
physiology Female Gene Expression Profiling Humans Oocytes / metabolism*, physiology Signal Transduction |
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