Document Detail


The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome.
MedLine Citation:
PMID:  20435609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is widely recognized that bi-directional communication exists between the human oocyte and cumulus cells (CCs) which is essential for the production of competent oocytes. CCs originate from granulosa cells (GCs) which differentiate into mural GCs and CCs during follicular antrum formation. CCs are biologically distinct from other follicular cells and perform specialized roles, transmitting signals within the ovary and supporting oocyte growth and maturation during the later stages of follicular development. This review details the results of transcriptomic analysis of CCs and considers what this data can teach us about the biology of CCs and their interactions with the oocyte. We also explore the potential for the gene expression data to reveal novel biomarkers of oocyte quality and assist the optimization of assisted reproductive technologies.
Authors:
Zhongwei Huang; Dagan Wells
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-29
Journal Detail:
Title:  Molecular human reproduction     Volume:  16     ISSN:  1460-2407     ISO Abbreviation:  Mol. Hum. Reprod.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513710     Medline TA:  Mol Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  715-25     Citation Subset:  IM    
Affiliation:
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Oxford, UK.
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MeSH Terms
Descriptor/Qualifier:
Cumulus Cells / metabolism*,  physiology
Female
Gene Expression Profiling
Humans
Oocytes / metabolism*,  physiology
Signal Transduction

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