Document Detail


The human obesity gene map: the 1996 update.
MedLine Citation:
PMID:  9061716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An update of the human obesity gene map up to October 1996 is presented. Evidence from Mendelian disorders exhibiting obesity as a clinical feature, single-gene mutation rodent models, quantitative trait loci uncovered in crossbreeding experiments with mouse, rat, and pig models, association and case-control studies with candidate genes, and linkage studies with genes and other markers is reviewed. All chromosomal locations of the animal loci are converted into human genome locations based on syntenic relationships between the genomes. A complete listing of all these loci reveals that only 4 of the 24 human chromosomes are not yet represented, i.e., 9, 18, 21, and Y. Several chromosome arms are characterized by the presence of several putative loci. The following arms include at least three such loci: 1p, 1q, 3p, 4q, 6p, 7q, 8p, 8q, 11p, 11q, 15q, 20q, and Xq. Studies with negative association and linkage results are also reviewed.
Authors:
L Pérusse; Y C Chagnon; F T Dionne; C Bouchard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Obesity research     Volume:  5     ISSN:  1071-7323     ISO Abbreviation:  Obes. Res.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-15     Completed Date:  1997-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305691     Medline TA:  Obes Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-61     Citation Subset:  IM    
Affiliation:
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Mapping*
Humans
Linkage (Genetics)
Mice
Mutation
Obesity / genetics*
Rats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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