Document Detail

A human moderately repeated Y-specific DNA sequence is evolutionarily conserved in the Y chromosome of the great apes.
MedLine Citation:
PMID:  1612595     Owner:  NLM     Status:  MEDLINE    
Evolutionary conservation of the human-derived moderately repeated Y-specific DNA sequence Y-190 (DYZ5) was investigated in the chimpanzee, orangutan, and gorilla. Southern blot analysis showed the presence of the sequence in the Y chromosome of all great apes. Pulsed-field gel electrophoresis and in situ hybridization revealed that the repeat is organized in one major block and confined to a small region of the Y chromosome of the three species. DYZ5 was assigned to the proximal short arm of the Y chromosome of the chimpanzee and orangutan and to the long arm of the Y chromosome of the gorilla. In light of its evolutionary conservation, DYZ5 may have an as yet undetermined structural function in the Y chromosome.
M Guttenbach; U Müller; M Schmid
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  13     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-7     Citation Subset:  IM    
Department of Human Genetics, University of Würzburg, Germany.
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MeSH Terms
Chromosome Banding
Genetic Markers*
Gorilla gorilla / genetics*
Nucleic Acid Hybridization
Pan troglodytes / genetics*
Pongo pygmaeus / genetics*
Repetitive Sequences, Nucleic Acid*
Sequence Homology, Nucleic Acid
Species Specificity
Y Chromosome*
Grant Support
Reg. No./Substance:
0/Genetic Markers

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