Document Detail

The human metapneumovirus: a case series and review of the literature.
MedLine Citation:
PMID:  21631655     Owner:  NLM     Status:  MEDLINE    
Human metapneumovirus (hMPV) is an emerging human pulmonary pathogen that is genetically related to respiratory syncytial virus. It has been increasingly associated with respiratory illnesses over the last few decades. Immunocompromised patients are particularly susceptible with resultant morbidity and mortality. We describe our experience with 9 immunocompromised patients diagnosed with pneumonia secondary to hMPV, 2 of whom were successfully treated with aerosolized and oral ribavirin along with intravenous immunoglobulin (IVIG). We suggest that hMPV should be considered in the differential diagnosis of immunocompromised patients with acute respiratory illness. Ribavirin (oral and aerosolized) with IVIG is potentially an effective treatment option for those with severe disease.
S Shahda; W G Carlos; P J Kiel; B A Khan; C A Hage
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-03
Journal Detail:
Title:  Transplant infectious disease : an official journal of the Transplantation Society     Volume:  13     ISSN:  1399-3062     ISO Abbreviation:  Transpl Infect Dis     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-02     Completed Date:  2011-10-17     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100883688     Medline TA:  Transpl Infect Dis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  324-8     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Department of Internal Medicine, Indiana University, Indianapolis, Indiana, USA.
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MeSH Terms
Antiviral Agents / therapeutic use
Hematopoietic Stem Cell Transplantation / adverse effects*
Immunocompromised Host
Immunoglobulins, Intravenous / therapeutic use
Lung Transplantation / adverse effects*
Middle Aged
Paramyxoviridae Infections* / drug therapy,  physiopathology,  virology
Respiratory Tract Infections* / drug therapy,  physiopathology,  virology
Ribavirin / therapeutic use
Treatment Outcome
Grant Support
T32 HL091816-03/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Antiviral Agents; 0/Immunoglobulins, Intravenous; 36791-04-5/Ribavirin

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