| The human immunodeficiency virus-1 genotype diversity and drug resistance mutations profile of volunteer blood donors from Chinese blood centers. | |
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MedLine Citation:
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PMID: 22044422 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The global human immunodeficiency virus (HIV)-1 epidemic is becoming increasingly diverse and complex. Molecular epidemiologic characteristics were studied for HIV-1-infected blood donors from five Chinese regions to determine genotype diversity and drug resistance mutations (DRMs) profile. STUDY DESIGN AND METHODS: HIV-1 confirmed-reactive serum samples were collected from 172 blood donors from five blood centers during 2007 to 2010. HIV-1 Pol including whole protease and partial reverse transcriptase genes was amplified, sequenced, and analyzed for the subtype determination and drug resistance profile description. RESULT: A total of 113 amplified sequences including 82 from Kunming blood center and 31 from four other blood centers had the following genotype characteristics: G (0.9%), B (2.7%), circulating recombinant form (CRF) 01_AE (32.7%), CRF07_BC (22.1%), and CRF08_BC (41.6%). Female donors represent 45.1% of all cases and 63.9% cases with DRMs. The prevalence of samples with potential low or higher resistance among Chinese blood donors is 4.4%. CONCLUSION: HIV-1 infection in Chinese blood donors is genetically diverse and the subtype distribution reflects that from the high-risk populations. Our results support continuous molecular epidemiologic surveillance for HIV-1 in blood donors as a part of a comprehensive HIV control program. |
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Authors:
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Peibin Zeng; Jingxing Wang; Yi Huang; Xiaoming Guo; Julin Li; Guoxin Wen; Tonghan Yang; Zhongqiao Yun; Miao He; Yu Liu; Yuzhe Yuan; Jane Schulmann; Simone Glynn; Paul Ness; J Brooks Jackson; Hua Shan; |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-2 |
Journal Detail:
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Title: Transfusion Volume: - ISSN: 1537-2995 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 American Association of Blood Banks. |
Affiliation:
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From the Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China; the Mianyang Blood Center, Mianyang, Sichuan, China; Guangxi Blood Center, Liuzhou, Guangxi, China; the Urumqi City Blood Center, Urumqi, Xinjiang, China; the Yunnan Kunming Blood Center, Kunming, Yunnan, China; the Luoyang Blood Center, Luoyang, Henan, China; Westat, Rockville, Maryland; NHLBI, Bethesda, Maryland; and Johns Hopkins University, Baltimore, Maryland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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