Document Detail


The human glutathione S-transferases: developmental aspects of the GST1, GST2, and GST3 loci.
MedLine Citation:
PMID:  4084207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of the GST1, GST2, and GST3 loci in fetal, neonatal, and infant tissues has been studied using starch gel electrophoresis and chromatofocusing. Each locus demonstrated developmental changes in expression, some of which were specific to a single tissue while others occurred in several tissues. GST1 was not usually expressed in any of the tissues studied before 30 weeks of gestation but steadily increased thereafter until adult levels were reached in late infancy. In neonates and older infants the frequencies of the GST1*0, GST1*1, and GST1*2 alleles were 0.79, 0.07, and 0.14, respectively. GST2 was always expressed in liver and adrenal but was only weakly expressed in spleen, cardiac muscle, and diaphragm. In kidney this locus was not usually expressed until nearly 1 year after birth. The GST3 isoenzymes were present in all fetal, neonatal, and infant tissues, although their expression in liver decreased after 30 weeks of gestation. Other isoenzymes with fast anodal mobilities were also identified in several tissues; these are believed to be GST3 isoenzymes that have undergone posttranslational modification rather than products of the putative GST4 locus. No specifically fetal isoenzymes were detected.
Authors:
R C Strange; B A Davis; C G Faulder; W Cotton; A D Bain; D A Hopkinson; R Hume
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical genetics     Volume:  23     ISSN:  0006-2928     ISO Abbreviation:  Biochem. Genet.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-02-20     Completed Date:  1986-02-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0126611     Medline TA:  Biochem Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1011-28     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromatography
Cytosol / enzymology
Electrophoresis, Starch Gel
Embryo, Mammalian / enzymology
Female
Fetus / enzymology
Gene Expression Regulation
Gestational Age
Glutathione Transferase / biosynthesis,  genetics,  isolation & purification*
Growth
Humans
Infant
Infant, Newborn
Isoenzymes / biosynthesis,  genetics,  isolation & purification*
Organ Specificity
Pregnancy
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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